PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
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PROTAC Linkers Related Products (4102)
Related Products (4102)
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PROTAC Linkers Isoform Comparison
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Mal-NH-PEG12-acid
0 ImagesCat. No.: HY-W876254CAS No.: 871133-36-7Mal-NH-PEG12-acid is a derivative of Mal-PEG12-acid (HY-140962). Mal-PEG12-acid is a PROTAC linker and belongs to the PEG class.
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Tert-butyl 2-(2-hydroxyethyl)-7-azaspiro[3.5]Nonane-7-carboxylate
![Tert-butyl 2-(2-hydroxyethyl)-7-azaspiro[3.5]Nonane-7-carboxylate](https://file.medchemexpress.com/product_pic/hy-w424240.gif "Click to View Tert-butyl 2-(2-hydroxyethyl)-7-azaspiro[3.5]Nonane-7-carboxylate Product Detail")
0 ImagesCat. No.: HY-W424240CAS No.: 1370210-93-7
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18-Mercaptooctadecanoic acid
0 ImagesCat. No.: HY-W614609CAS No.: 600730-11-8
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CbzNH-(C5-O)2-C4-Boc
0 ImagesCat. No.: HY-403544CAS No.: 2324147-95-5CbzNH-(C5-O)2-C4-Boc is a PROTAC linker. CbzNH-(C5-O)2-C4-Boc can be used for the synthesis of PROTAC CRBN-6-5-5-VHL (HY-136262).
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cis-3-[(Benzyloxy)methyl]cyclobutanol
![cis-3-[(Benzyloxy)methyl]cyclobutanol](https://file.medchemexpress.com/product_pic/hy-22345a.gif "Click to View cis-3-[(Benzyloxy)methyl]cyclobutanol Product Detail")
0 ImagesCat. No.: HY-22345ACAS No.: 172324-68-4
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Thiol-PEG5-alcohol
0 ImagesCat. No.: HY-133293CAS No.: 248582-03-8Synonyms: HS-PEG5-OH
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TBS-PEG4-COOH
0 ImagesCat. No.: HY-W614958CAS No.: 1807540-77-7
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Benzyl 2-(4-(bromomethyl)phenyl)acetate
0 ImagesCat. No.: HY-W651679CAS No.: 140233-65-4
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Ethyl 11-bromoundecanoate
0 ImagesCat. No.: HY-W013836CAS No.: 6271-23-4
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Piperazin-C3-OH dihydrochloride
0 ImagesCat. No.: HY-W115358CAS No.: 6427-02-7
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Boc-azetidine-piperazin dihydrochloride
0 ImagesCat. No.: HY-W130126CAS No.: 2061980-49-0
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tert-Butyl (7-oxoheptyl)carbamate
0 ImagesCat. No.: HY-24256CAS No.: 133728-25-3
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4-(4-Piperidyl)-1-butanol
0 ImagesCat. No.: HY-33023CAS No.: 57614-92-3Synonyms: 4-Piperidinebutanol
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17-((tert-Butoxycarbonyl)amino)heptadecanoic acid
0 ImagesCat. No.: HY-W883922CAS No.: 2443488-63-7
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tert-Butyl N-(2-azaspiro[3.3]heptan-6-yl)carbamate hydrochloride
![tert-Butyl N-(2-azaspiro[3.3]heptan-6-yl)carbamate hydrochloride](https://file.medchemexpress.com/product_pic/hy-20239a.gif "Click to View tert-Butyl N-(2-azaspiro[3.3]heptan-6-yl)carbamate hydrochloride Product Detail")
0 ImagesCat. No.: HY-20239ACAS No.: 1956355-97-7
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1-(1-(3-Chloropropyl)piperidin-4-yl)ethan-1-ol
0 ImagesCat. No.: HY-W357971CAS No.: 49620-32-8
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Benzyl (6-aminohexyl)carbamate hydrochloride
0 ImagesCat. No.: HY-W097113CAS No.: 78618-06-1
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1-(Piperidin-4-yl)azetidin-3-ol dihydrochloride
0 ImagesCat. No.: HY-W248194CAS No.: 1537465-19-2
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Di-tert-butyl decanedioate
0 ImagesCat. No.: HY-W415282CAS No.: 143050-66-2
