PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
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PROTAC Linkers Related Products (4102)
Related Products (4102)
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PROTAC Linkers Isoform Comparison
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tert-Butyl 4-(2-Aminoethyl)-3,3-difluoropiperidine-1-carboxylate
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TBS-PEG5-OH
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Methyl 5-oxopentanoate
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2-(3-(Aminomethyl)phenyl)acetic acid
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Deca-1,9-diyne
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4-(4-(tert-Butoxycarbonyl)piperazin-1-yl)-4-oxobutanoic acid
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Tert-butyl 4-(4-(hydroxymethyl)benzyl)piperazine-1-carboxylate
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HO-PEG3-(CH2)6-Cl
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Ph-PEG5-Br
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(((6-Bromohexyl)oxy)methyl)benzene
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Tert-butyl 3-(((benzyloxy)carbonyl)amino)propanoate
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Phenylmethyl N-(5-bromopentyl)carbamate
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N-(m-PEG4)-N'-(biotin-PEG3)-Cy5
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