PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
All Product Categories
-
PROTAC Linkers Related Products (4102)
Related Products (4102)
-
PROTAC Linkers Isoform Comparison
-
tert-Butyl 4-(piperidin-3-ylmethyl)piperazine-1-carboxylate dihydrochloride
0 ImagesCat. No.: HY-W377732CAS No.: 1211498-87-1
-
N,N'-(Pentane-1,5-diyl)bis(2-chloroacetamide)
0 ImagesCat. No.: HY-W175189CAS No.: 33619-33-9
-
2-Bromo-N-(but-3-yn-1-yl)acetamide
0 ImagesCat. No.: HY-W172608CAS No.: 1204333-33-4
-
NH2-C6-O-C5-O-C4-COOH
0 ImagesCat. No.: HY-W1130286
-
Cbz-NH-PEG3-tosyl
0 ImagesCat. No.: HY-W580126CAS No.: 2098983-15-2
-
(R)-tert-Butyl 3-(2-aminoethyl)pyrrolidine-1-carboxylate
0 ImagesCat. No.: HY-W069358CAS No.: 1420537-04-7
-
Methyl 6-aminospiro[3.3]heptane-2-carboxylate hydrochloride
![Methyl 6-aminospiro[3.3]heptane-2-carboxylate hydrochloride](https://file.medchemexpress.com/product_pic/hy-w057096.gif "Click to View Methyl 6-aminospiro[3.3]heptane-2-carboxylate hydrochloride Product Detail")
0 ImagesCat. No.: HY-W057096CAS No.: 1808249-67-3
-
(4-Oxo-4H-quinazolin-3-yl)-acetic acid
0 ImagesCat. No.: HY-W030545CAS No.: 14663-53-7
-
PEG3-I
0 ImagesCat. No.: HY-W442226CAS No.: 62573-16-4
-
Tetrahydro-2-[[(3E)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-buten-1-yl]oxy]-2H-pyran
![Tetrahydro-2-[[(3E)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-buten-1-yl]oxy]-2H-pyran](https://file.medchemexpress.com/product_pic/hy-w614686.gif "Click to View Tetrahydro-2-[[(3E)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-buten-1-yl]oxy]-2H-pyran Product Detail")
0 ImagesCat. No.: HY-W614686CAS No.: 313342-78-8
-
tert-Butyl 4-(2-aminoethyl)-3-oxopiperazine-1-carboxylate
0 ImagesCat. No.: HY-W102038CAS No.: 234108-58-8
-
Tert-butyl (2-aminospiro[3.5]nonan-7-yl)(methyl)carbamate
![Tert-butyl (2-aminospiro[3.5]nonan-7-yl)(methyl)carbamate](https://file.medchemexpress.com/product_pic/hy-w975085.gif "Click to View Tert-butyl (2-aminospiro[3.5]nonan-7-yl)(methyl)carbamate Product Detail")
0 ImagesCat. No.: HY-W975085CAS No.: 2434852-79-4
-
2-(Hydroxymethyl)cyclopropanecarbonitrile
0 ImagesCat. No.: HY-W563272CAS No.: 30491-95-3
-
But-3-yn-1-yl methanesulfonate
0 ImagesCat. No.: HY-W259141CAS No.: 72486-09-0
-
tert-Butyl (3-(chlorosulfonyl)propyl)carbamate
0 ImagesCat. No.: HY-W616788CAS No.: 1196153-59-9
-
2-(2,6-Dimethylpiperazin-1-yl)ethan-1-amine
0 ImagesCat. No.: HY-W840623CAS No.: 468745-67-7
-
[1,1'-Bi(cyclohexane)]-4,4'-diol
![[1,1'-Bi(cyclohexane)]-4,4'-diol](https://file.medchemexpress.com/product_pic/hy-w009813.gif "Click to View [1,1'-Bi(cyclohexane)]-4,4'-diol Product Detail")
0 ImagesCat. No.: HY-W009813CAS No.: 20601-38-1
-
Tert-butyl n-methyl-N-[2-(piperidin-4-yl)ethyl]carbamate
![Tert-butyl n-methyl-N-[2-(piperidin-4-yl)ethyl]carbamate](https://file.medchemexpress.com/product_pic/hy-w198256.gif "Click to View Tert-butyl n-methyl-N-[2-(piperidin-4-yl)ethyl]carbamate Product Detail")
0 ImagesCat. No.: HY-W198256CAS No.: 171049-32-4
