PROTACs
PROTAC (PROteolysis-TArgeting Chimera) is a heterobifunctional nanomolecule containing two different ligands, ligand for ubiquitin E3 and ligand for target protein. The two parts are connected by linker to form a "three-unit" polymer, target protein ligand-linker-E3 ligase ligand. Building blocks of PROTAC molecules include PROTAC Linker, Ligand for Target Protein for PROTAC, Ligand for E3 Ligase, E3 Ligase Ligand-Linker Conjugate, Target Protein Ligand-Linker Conjugate, etc.
PROTACs Isoform Specific Products
All Product Categories
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PROTACs Related Products (1353)
Related Products (1353)
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Antibodies (1)
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PROTACs Isoform Comparison
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PROTAC B-Raf degrader 1 (Standard)
0 ImagesCat. No.: HY-111758RCAS No.: 2364367-27-9PROTAC B-Raf degrader 1 (Standard) is the analytical standard of PROTAC B-Raf degrader 1 (HY-111758). This product is intended for research and analytical applications. PROTAC B-Raf degrader 1 (compound 2) is a proteolysis targeting chimera (PROTAC) for the degradation of B-Raf based on Cereblon ligand with anti-cancer activity.
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BSJ-03-123 (Standard)
0 ImagesCat. No.: HY-111556RCAS No.: 2361493-16-3BSJ-03-123 (Standard) is the analytical standard of BSJ-03-123 (HY-111556). This product is intended for research and analytical applications. BSJ-03-123 is a PROTAC connected by ligands for Cereblon and CDK as a potent and novel CDK6-selective small-molecule degrader.
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dBET1 (Standard)
0 ImagesdBET1 (Standard) is the analytical standard of dBET1 (HY-101838). This product is intended for research and analytical applications. dBET1 is a PROTAC connected by ligands for Cereblon and BRD4 with an EC50 of 430 nM. dBET1 is a PROTAC that composes of (+)-JQ1 (HY-13030) linked to NSC 527179 (HY-14658) with a linker.
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PROTAC BET Degrader-1 (Standard)
0 ImagesCat. No.: HY-103633RCAS No.: 2093386-22-0PROTAC BET Degrader-1 (Standard) is the analytical standard of PROTAC BET Degrader-1 (HY-103633). This product is intended for research and analytical applications. PROTAC BET Degrader-1 is a BRD2/BRD3/BRD4 PROTAC degrader. PROTAC BET Degrader-1 inhibits the growth of acute leukemia cells. PROTAC BET Degrader-1 is applicable to the research of acute leukemia.
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PROTAC HBeAg degrader-1
0 ImagesCat. No.: HY-174856PROTAC HBeAg degrader-1 is a PROTAC targeting degradation agent for HBeAg. PROTAC HBeAg degrader-1 recruits the VHL E3 ligase but degrades HBV protein HBeAg through VHL-independent mechanism. PROTAC HBeAg degrader-1 decreases levels of secreted and intracellular HBeAg. PROTAC HBeAg degrader-1 can be used for the research of hepatitis B virus (HBV).
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ZXH-8-004
0 ImagesCat. No.: HY-161806ZXH-8-004 is a DENV E PROTAC degrader with a DC50 value of 0.21 µM in Huh7.5 cells. ZXH-8-004 induces CRBN- and proteasome-dependent degradation of intracellular dengue virus envelope protein. ZXH-8-004 inhibits envelope-mediated membrane fusion during viral entry and reduces the production of infectious dengue virus particles. ZXH-8-004 can be used in studies related to dengue virus infection, Zika virus infection, Japanese encephalitis virus infection, West Nile virus infection, and yellow fever virus infection.
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ZBP1 PROTAC-1
0 ImagesCat. No.: HY-185102ZBP1 PROTAC-1 is a Z-DNA-binding protein 1 (ZBP1) PROTAC degrader with a DC50 of 25.69 nM. ZBP1 PROTAC-1 consists of a DNA aptamer that specifically binds to ZBP1 and an E3 enzyme-recruiting moiety. ZBP1 PROTAC-1 combines the specificity and covalent binding ability of DNA aptamers with the PROTAC-mediated degradation function. By degrading ZBP1, ZBP1 PROTAC-1 inhibits the phosphorylation of RIPK3/MLKL to necrotic apoptosis and reduces the levels of proinflammatory cytokines (IL-18, IL-1β, IL-6, TNF-α, IFN-β). ZBP1 PROTAC-1 can be used in the research of viral pneumonia and influenza A H1N1 virus infection.
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PROTAC ERα Degrader-2 (Standard)
0 ImagesCat. No.: HY-111846RCAS No.: 1351169-29-3PROTAC ERα Degrader-2 (Standard) is the analytical standard of PROTAC ERα Degrader-2 (HY-111846). This product is intended for research and analytical applications. PROTAC ERα Degrader-2 (Compound 11) is a ERα PROTAC degrader. PROTAC ERα Degrader-2 significantly down-regulates the level of ERα in MCF-7 cells.(Pink: AR ligand (HY-43962), Blue: IAP Ligand (HY-177389), Black: Linker (HY-128833)).
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SNIPER(BRD)-1 (Standard)
0 ImagesCat. No.: HY-111875RCAS No.: 2095244-54-3SNIPER(BRD)-1 (Standard) is the analytical standard of SNIPER(BRD)-1 (HY-111875). This product is intended for research and analytical applications. SNIPER(BRD)-1 is a SNIPER degrader of BRD4, cIAP1 and XIAP. SNIPER(BRD)-1 has IC50 values of 6.8 nM, 17 nM and 49 nM for cIAP1, cIAP2 and XIAP, respectively. SNIPER(BRD)-1 can be used for cancer research. (Blue: LCL161 (HY-15518); Black: linker (HY-W008005); Pink: (+)-JQ-1 (HY-13030))
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dTAG-Fluorescein
0 ImagesCat. No.: HY-183439CAS No.: 2365116-48-7dTAG-Fluorescein is a fluorescent acceptor probe and heterobifunctional proteolysis targeting chimeric molecule (PROTAC).dTAG-Fluorescein functions in Homogeneous Time Resolved Fluorescence (HTRF) competitive displacement binding assays to measure binding affinity to His-FKBP12(F36V).dTAG-Fluorescein recruits von Hippel-Lindau or CRBN E3 ligase complexes to drive selective degradation of FKBP12F36V-tagged proteins, with limited activity towards FKBP12WT and IKZF1.
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PROTAC BRD4 Degrader-49
0 ImagesCat. No.: HY-185854CAS No.: 3115940-40-1BRD4 degrader-8 is a BRD4-targeting degrader. BRD4 degrader-8 induces degradation of BRD4 protein via the ubiquitin-proteasome pathway. BRD4 degrader-8 can be used for the research of hematologic tumors, gastrointestinal stromal tumors, histiocytic lymphoma, non-small cell lung cancer, small cell lung cancer, lung adenocarcinoma, lung squamous cell carcinoma, pancreatic cancer, breast cancer, prostate cancer, liver cancer, skin cancer, epithelial cell carcinoma, colorectal cancer, kidney cancer, gastric cancer, head and neck cancer, nasopharyngeal cancer.
