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Cat. No.: HY-184846

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PROTAC Nrf2 degrader-1

PROTAC Nrf2 degrader-1 is a PROTAC degrader targeting Nrf2, with IC₅₀ values of 10 nM and 3 nM in A549 cells and LK-2 cells, respectively. PROTAC Nrf2 degrader-1 can be used in cancer research.
(Pink: Nrf2 Target protein ligand; Blue: Cereblon ligand (HY-132226); Black: linker).

For research use only. We do not sell to patients.

CAS No.: 3025286-29-4
Formula: C₄₂H₄₁FN₈O₇S
Molecular Weight:820.89

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

PROTAC Nrf2 degrader-1 Chemical Structure

CAS No.: 3025286-29-4

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

PROTAC Nrf2 degrader-1 is a PROTAC degrader targeting Nrf2, with IC₅₀ values of 10 nM and 3 nM in A549 cells and LK-2 cells, respectively. PROTAC Nrf2 degrader-1 can be used in cancer research^[1]. (Pink: Nrf2 Target protein ligand; Blue: Cereblon ligand (HY-132226); Black: linker).

IC₅₀ & Target^[1]

Nrf2

All PROTACs Isoforms :

In Vitro

PROTAC Nrf2 degrader-1 potently degrades Nrf2 in A549 cells with an IC₅₀ of 0.01 μM (n=2) and in LK-2 cells with an IC₅₀ of 0.003 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3025286-29-4
Molecular Weight 820.89
Formula C₄₂H₄₁FN₈O₇S
SMILES

O=C(N1C2=CC=C(C3=C(C)SC(NC(CC4=CC=C(C(OCCOCCNC5=CC=C6C(N(C7C(NC(CC7)=O)=O)CC6=C5)=O)=C4)F)=O)=N3)C=C2CC1)C8=CN=CN8C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Munroe JE, Wild RC. Compounds and uses thereof. WO 2024006742 A2. Published January 4, 2024. PCT/US2023/069147.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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PROTAC Nrf2 degrader-1

All PROTACs Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

PROTAC Nrf2 degrader-1 Related Classifications

HY-184846 Related Classifications