2365116-48-7

dTAG-Fluorescein Chemical Structure
2365116-48-7

Chemical Structure

dTAG-Fluorescein

  • CAS No.: 2365116-48-7
  • Formula:C59H60N2O15
  • Molecular Weight:1037.11

InChIKey: PYSNCVLWRQOZJE-UWPQOEEGSA-N

SMILES: O=C1OC2(C3=CC=C(O)C=C3OC4=CC(O)=CC=C42)C5=CC(C(NCCOC6=CC([C@@H](CCC7=CC(OC)=C(C=C7)OC)OC([C@H]8N(CCCC8)C([C@H](C9=CC(OC)=C(C(OC)=C9)OC)CC)=O)=O)=CC=C6)=O)=CC=C51

Biological Activity: dTAG-Fluorescein is a dTAG-class PROTAC conjugated with fluorescein. dTAG-Fluorescein is applicable to homogeneous time-resolved fluorescence (HTRF) competitive displacement binding assays to detect binding affinity with His-FKBP12F36V. dTAG-Fluorescein can recruit VHL or CRBN E3 ligase complexes, thereby specifically driving the selective degradation of FKBP12F36V-tagged proteins, with very limited activity against FKBP12WT and IKZF1[1][2][3][4][5].

Cat. No. Product Name Purity Description Pricing
HY-183439 		dTAG-Fluorescein dTAG-Fluorescein is a dTAG-class PROTAC conjugated with fluorescein. dTAG-Fluorescein is applicable to homogeneous time-resolved fluorescence (HTRF) competitive displacement binding assays to detect binding affinity with His-FKBP12F36V. dTAG-Fluorescein can recruit VHL or CRBN E3 ligase complexes, thereby specifically driving the selective degradation of FKBP12F36V-tagged proteins, with very limited activity against FKBP12WT and IKZF1.
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