RUNX
Runt-related transcription factors; RUNX
Runt-related transcription factors (RUNX) is a transcription factor that regulates the bone development, cell growth and tumor metastasis. There are three RUNX transcription factors in mammals: RUNX1, RUNX2 and RUNX3. RUNX1 is expressed in mesenchymal cells and proliferating chondrocytes, and acts as a compensatory factor for RUNX2 to promote the proliferation and differentiation of osteoblasts; RUNX1 is also expressed in hematopoietic cells and certain cancer cells. RUNX2 is expressed in bones and chondrocytes, and is a key regulator of osteoblast differentiation and chondrocyte hypertrophy. RUNX2 is also highly expressed in the nucleus and cytoplasm of prostate cancer cells, that binds to microtubules in the cytoplasm and is associated with the tumor metastasis. RUNX3 is expressed in hypertrophic chondrocytes plays an anabolic function in cartilage metabolism, and maintains the health of cartilage by regulating the expression of genes such as Acan and Prg4. Runt-related transcription factors dysfunction leads to bone diseases like osteoporosis, skeletal abnormality or osteoarthritis. In addition, runt-related transcription factors is abnormal expressed in certain cancer cells, which is supposed to be associated with tumor development[1][2].
References:
- [1]. Hojo H, et al., Runt-related Transcription Factors and Gene Regulatory Mechanisms in Skeletal Development and Diseases. Curr Osteoporos Rep. 2023 Oct;21(5):485-492. [Content Brief]
- [2]. Ashe H, et al., Role of the runt-related transcription factor (RUNX) family in prostate cancer. FEBS J. 2021 Nov;288(21):6112-6126. [Content Brief]
RUNX Isoform Specific Products
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RUNX Related Products (28)
Related Products (28)
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RUNX Isoform Comparison
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Potassium dihydrogen phosphate, meets analytical specification of Ph. Eur., NF, E340
0 ImagesSynonyms: Potassium phosphate monobasic, meets analytical specification of Ph. Eur., NF, E340Potassium dihydrogen phosphate, meets analytical specification of Ph. Eur., NF, E340 (Potassium phosphate monobasic, meets analytical specification of Ph. Eur., NF, E340) is a potassium salt. Potassium dihydrogen phosphate, meets analytical specification of Ph. Eur., NF, E340 activates NF-κB. Potassium dihydrogen phosphate, meets analytical specification of Ph. Eur., NF, E340 upregulates the expression of dental/osteogenic markers (OCN, DSP/DSPP, OSX, RUNX2, ALP) and enhances the mineralization capacity of human periodontal ligament stem cells. Potassium dihydrogen phosphate, meets analytical specification of Ph. Eur., NF, E340 promotes the proliferation of human periodontal ligament stem cells in logarithmic growth phase. Potassium dihydrogen phosphate, meets analytical specification of Ph. Eur., NF, E340 promotes the growth of somatic embryos of Dendrobium Sonia, increases leaf number, leaf length and fresh weight of tissue-cultured seedlings. Potassium dihydrogen phosphate, meets analytical specification of Ph. Eur., NF, E340 is applicable to periodontal disease-related research.
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Runx1-CBFβ interaction inhibitor 1
0 ImagesCat. No.: HY-124137CAS No.: 493028-20-9Runx1-CBFβ interaction inhibitor 1 is an allosteric inhibitior of Runt domain-CBFb interaction (IC50=3.2 μM).
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Largazole
0 ImagesCat. No.: HY-13906CAS No.: 1009815-87-5Synonyms: (+)-LargazoleLargazole ((+)-Largazole) is an orally active, blood-brain barrier-permeable class I histone deacetylase (HDAC) inhibitor with in vivo anticancer activity and osteogenic efficacy. As a prodrug, Largazole hydrolyzes to Largazole thiol (HY-170890), which has a Ki value of 0.07 nM against human HDAC2. Largazole regulates the cell cycle, induces apoptosis, upregulates tumor suppressors and osteoblast differentiation markers, inhibits osteoclast formation, and upregulates neuroprotection-related genes. Largazole can be used in the research of various cancers including colorectal cancer, as well as neurodegenerative diseases.
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Potassium dihydrogen phosphate, for molecular biology
0 ImagesSynonyms: Potassium phosphate monobasic, for molecular biologyPotassium dihydrogen phosphate, for molecular biology (Potassium phosphate monobasic, for molecular biology) is a potassium salt. Potassium dihydrogen phosphate, for molecular biology activates NF-κB. Potassium dihydrogen phosphate, for molecular biology upregulates the expression of dental/osteogenic markers (OCN, DSP/DSPP, OSX, RUNX2, ALP) and enhances the mineralization capacity of human periodontal ligament stem cells. Potassium dihydrogen phosphate, for molecular biology promotes the proliferation of human periodontal ligament stem cells in logarithmic growth phase. Potassium dihydrogen phosphate, for molecular biology promotes the growth of somatic embryos of Dendrobium Sonia, increases leaf number, leaf length and fresh weight of tissue-cultured seedlings. Potassium dihydrogen phosphate, for molecular biology is applicable to periodontal disease-related research.
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Withanolide B (Standard)
0 ImagesCat. No.: HY-129566RCAS No.: 56973-41-2Withanolide B (Standard) is the analytical standard of Withanolide B. This product is intended for research and analytical applications. Withanolide B is an active component of W. somnifera Dunal. Withanolide B promotes osteogenic differentiation of hBMSCs via ERK1/2 and Wnt/β-catenin signaling pathways. Withanolide B exhibits neuroprotective, anti-arthritic, anti-aging and anti-cancer effects.
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Ro5-3335 (Standard)
0 ImagesCat. No.: HY-108470RCAS No.: 30195-30-3Ro5-3335 (Standard) is the analytical standard of Ro5-3335 (HY-108470). This product is intended for research and analytical applications. Ro5-3335, a benzodiazepine, acts as an inhibitor of core binding factor (CBF) leukemia. Ro5-3335 is a RUNX1-CBFβ interaction inhibitor that represses RUNX1/CBFB-dependent transactivation.
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Anti-osteoporosis agent-6
0 ImagesCat. No.: HY-155985CAS No.: 445231-36-7Anti-osteoporosis agent-6 (compound 174) is an anti-osteoporosis agent. Anti-osteoporosis agent-6 has 14.11% inhibition rate against osteoclast formation at 10 μM.
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Magnesium malate
0 ImagesMagnesium malate is an orally active organic acid-chelated magnesium complex. Magnesium malate promotes the release of prostaglandin E2 (PGE2) from macrophages, synergistically stimulates the synthesis/release of calcitonin gene-related peptide (CGRP) from dorsal root ganglion neurons, and upregulates the osteogenic transcription factor RUNX2 in osteoblasts via the Mg2+-PGE2-CGRP axis, thereby promoting osteoblast proliferation. Magnesium malate can be incorporated into calcium phosphate bone cement as a modifying component to improve compressive strength, shorten setting time and enhance disintegration resistance. Magnesium malate increases serum magnesium levels. Magnesium malate can be used in studies related to bone defects and magnesium deficiency.
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