1. Signaling Pathways
  2. Cell Cycle/DNA Damage
    Epigenetics
  3. Sirtuin
  4. SIRT2 Isoform
  5. SIRT2 Inhibitor

SIRT2 Inhibitor

SIRT2 Inhibitors (34):

Cat. No. Product Name Effect Purity
  • HY-B0150
    Nicotinamide
    Inhibitor 99.86%
    Nicotinamide is a form of vitamin B3 or niacin that inhibits sirtuin 2 (SIRT2) activity in vitro, with an EC50 of 2 μM.
  • HY-108331
    3-TYP
    Inhibitor 99.93%
    3-TYP is a selective SIRT3 inhibitor, with an IC50 of 16 nM, more potent over SIRT1 (IC50=88 nM), SIRT2 (IC50=92 nM).
  • HY-107454
    OSS_128167
    Inhibitor 98.06%
    OSS_128167 is a potent selective sirtuin 6 (SIRT6) inhibitor with IC50s of 89 μM, 1578 μM and 751 μM for SIRT6, SIRT1 and SIRT2, respectively.
  • HY-B0879A
    Suramin sodium salt
    Inhibitor 99.48%
    Suramin sodium salt (Suramin hexasodium salt) is a reversible and competitive protein-tyrosine phosphatases (PTPases) inhibitor.
  • HY-147233
    MIND4-19
    Inhibitor 99.94%
    MIND4-19 is a potent SIRT2 inhibitor with an IC50 value of 7.0 μM.
  • HY-148408
    SIRT2-IN-11
    Inhibitor
    SIRT2-IN-11 (AEM1) is a selective SIRT2 inhibitor with an IC50 value of 18.5 μM.
  • HY-150727
    SIRT5 inhibitor 4
    Inhibitor
    SIRT5 inhibitor 4 (compound 11) is a potent, selective SIRT5 inhibitor with IC50 values of 26.4 and >400μM for SIRT5 and other SIRT subtype, respectively.
  • HY-100578
    AGK2
    Inhibitor 99.62%
    AGK2 is a selective SIRT2 inhibitor with an IC50 of 3.5 μM.
  • HY-13515
    Sirtinol
    Inhibitor ≥98.0%
    Sirtinol is a sirtuin (SIRT) inhibitor, with IC50s of 48 μM, 57.7 μM and 131 μM for ySir2, hSIRT2 and hSIRT2, respectively.
  • HY-101278
    Thiomyristoyl
    Inhibitor 98.37%
    Thiomyristoyl is a potent and specific SIRT2 inhibitor with an IC50 of 28 nM.
  • HY-15510
    Tenovin-6
    Inhibitor 98.67%
    Tenovin-6, an analog of Tenovin-1 (HY-13423), is an activator of p53 transcriptional activity.
  • HY-100732
    Cambinol
    Inhibitor 99.70%
    Cambinol is a SIRT1 and SIRT2 inhibitor with IC50 values of 56 μM and 59 μM, respectively.
  • HY-16691
    AK-7
    Inhibitor 99.93%
    AK-7 is a selective cell- and brain-permeable SIRT2 inhibitor, with an IC50 of 15.5 μM.
  • HY-103636
    PROTAC Sirt2 Degrader-1
    Inhibitor 98.50%
    PROTAC Sirt2 Degrader-1 is a SirReal-based PROTAC, acts as a Sirt2 degrader, composed of a highly potent and isotype-selective Sirt2 inhibitor, a linker, and a bona fide Cereblon ligand for E3 ubiquitin ligase.
  • HY-100591
    SirReal2
    Inhibitor 99.12%
    SirReal2 is a potent, isotype-selective Sirt2 inhibitor with an IC50 value of 140 nM and has very little effect on the activities of Sirt3-5.
  • HY-101073
    Salermide
    Inhibitor ≥98.0%
    Salermide is an inhibitor of Sirt1 and Sirt2; can cause strong cancer-specific apoptotic cell death.
  • HY-101465
    AK-1
    Inhibitor 99.97%
    AK-1 is a potent, specific and cell-permeable SIRT2 inhibitor, with an IC50 of 12.5 μM.
  • HY-112427
    Sirt2-IN-1
    Inhibitor 98.45%
    Sirt2-IN-1 (Compound 9) is a sirtuin 2 (Sirt2) inhibitor with an IC50 of 163 nM.
  • HY-16616
    SIRT-IN-2
    Inhibitor 98.56%
    SIRT-IN-2 is a potent inhibitor of SIRT1/2/3, with IC50s of 4, 4, 7 μM, respectively.
  • HY-15510B
    Tenovin-6 Hydrochloride
    Inhibitor ≥98.0%
    Tenovin-6 Hydrochloride, an analog of Tenovin-1 (HY-13423), is an activator of p53 transcriptional activity.