14513-15-6
14513-15-6
Chemical Structure
Cambinol
- CAS. Nr.: 14513-15-6
- Formula:C21H16N2O2S
- Molecular Weight:360.43
IUPAC Name: 5-((2-hydroxynaphthalen-1-yl)methyl)-6-phenyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one
InChIKey: RVNSQVIUFZVNAU-UHFFFAOYSA-N
SMILES: O=C(C(CC1=C2C=CC=CC2=CC=C1O)=C(C3=CC=CC=C3)N4)NC4=S
Biological Activity: Cambinol is a SIRT1 and SIRT2 inhibitor with IC50 values of 56 μM and 59 μM, respectively. Cambinol is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor)[1][2].
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Cambinol | 99.89% | Cambinol is a SIRT1 and SIRT2 inhibitor with IC50 values of 56 μM and 59 μM, respectively. Cambinol is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor). | ||||||||||||||||||||
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Cambinol (Standard) | ≥98% | Cambinol (Standard) is the analytical standard of Cambinol. This product is intended for research and analytical applications. Cambinol is a SIRT1 and SIRT2 inhibitor with IC50 values of 56 μM and 59 μM, respectively. Cambinol is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor). | ||||||||||||||||||||
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References
- [1]. Heltweg B, et al. Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes. Cancer Res. 2006 Apr 15;66(8):4368-77. [Content Brief]
- [2]. Huarui Zhang, et al. Advances in the discovery of exosome inhibitors in cancer. J Enzyme Inhib Med Chem. 2020 Dec;35(1):1322-1330. [Content Brief]
Keywords
