Urotensin Receptor
UT receptor
Urotensin receptor (UT) is a G-protein coupled receptor which binds the peptide hormoneurotensin. The urotensin-II (UT) receptor is a Gq/11-protein-coupled receptor that mediates complex hemodynamic effects and influences neuromuscular physiology. The UT receptor displays greatest expression levels in the peripheral vasculature, heart and kidney, although they are found elsewhere, notably the central nervous system, at lower levels. The UT receptor produces potent but variable vasoconstrictor effects in some vascular beds, yet mediates vasodilation in others; it has also been implicated in osmoregulation.
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Urotensin Receptor Related Products (34)
Related Products (34)
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UPG-111
0 ImagesCat. No.: HY-P11259CAS No.: 3090687-02-5UPG-111 is a peptide compound that acts as a negative allosteric modulator of the Urotensin II receptor (UTR). UPG-111 exhibits a dual inhibitory effect on the vasoconstriction induced by UTR agonists - it reduces both the maximum response intensity and the sensitivity of the agonist. UPG-111 does not induce calcium release or cause contraction of the endothelium-deprived rat aortic rings. UPG-111 can be used for the study of various diseases related to the angiotensinergic system.
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UFP-803
0 ImagesCat. No.: HY-P1166CAS No.: 879497-82-2UFP-803 is a potent urotensin-II receptor (UT) ligand. UFP-803 has lower residual agonist activity, so it may be an important tool for the investigations on the role played by the UT system in physiology and pathology.
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[Orn5]-URP
![[Orn5]-URP](https://file.medchemexpress.com/product_pic/hy-p1167.gif "Click to View [Orn5]-URP Product Detail")
0 ImagesCat. No.: HY-P1167CAS No.: 782485-03-4[Orn5]-URP is a potent and selective pure antagonist of Urotensin-II receptor (UT), with an pEC50 of 7.24. [Orn5]-URP displays no agonist activity.
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SB-657510 (Standard)
0 ImagesCat. No.: HY-10656RCAS No.: 474960-44-6SB-657510 (Standard) is the analytical standard of SB-657510 (HY-10656). This product is intended for research and analytical applications. SB-657510 is a selective urotensin II (UII) receptor (UT) antagonist. The Ki values are 61, 17, 30, 65 and 56 nM for human, monkey, cat, rat and mouse receptors, respectively. SB-657510 exerts anti-inflammatory effects by inhibiting UII-induced upregulation of inflammatory mediators such as adhesion molecules, cytokines, and tissue factor in human vascular endothelial cells.
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AC-7954 free base
0 ImagesCat. No.: HY-129648CAS No.: 734528-95-1AC-7954 free base is a selective nonpeptidic urotensin receptor agonist (EC50: 300 nM at the human UII receptor).
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Palosuran hydrochloride (Standard)
0 ImagesCat. No.: HY-10655ARCAS No.: 2469274-58-4Synonyms: ACT-058362 hydrochloride (Standard)Palosuran (hydrochloride) (Standard) is the analytical standard of Palosuran (hydrochloride). This product is intended for research and analytical applications. Palosuran hydrochloride (ACT-058362 hydrochloride) is a potent, selective, and orally active antagonist of urotensin II receptor, with an IC50 of 3.6 nM for CHO cell membranes expressing human recombinant receptors. Palosuran hydrochloride can improves pancreatic and renal function in diabetic rats.
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[Orn8]-Urotensin II (human)
![[Orn8]-Urotensin II (human)](https://file.medchemexpress.com/product_pic/hy-p1168.gif "Click to View [Orn8]-Urotensin II (human) Product Detail")
0 ImagesCat. No.: HY-P1168CAS No.: 479065-85-5[Orn8]-Urotensin II (human), a peptide analog of urotensin II, is a UT receptor agonist. [Orn8]-Urotensin II (human) increases intracellular calcium levels in HEK293.
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AC-7954
0 ImagesCat. No.: HY-10658CAS No.: 477313-09-0AC-7954 is a selective nonpeptidic urotensin receptor agonist (EC50: 300 nM at the human UII receptor).
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SB-706375 (Standard)
0 ImagesCat. No.: HY-10657RCAS No.: 733734-61-7SB-706375 (Standard) is the analytical standard of SB-706375 (HY-10657). This product is intended for research and analytical applications. SB-706375 is an antagonist of the Urotensin II (UII) receptor. By blocking the Urotensin II receptor, SB-706375 reduces the kidney's response to UII and Urotensin-related peptide (URP) and significantly increases the Glomerular Filtration Rate (GFR). SB-706375 can be used in research on kidney diseases and hypertension.
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GSK-1440115
0 ImagesCat. No.: HY-19924CAS No.: 1003878-16-7GSK-1440115 is an antagonist of the Urotensin II Receptor with an IC50 value of 82.3 nM.
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Palosuran (Standard)
0 ImagesCat. No.: HY-10655RCAS No.: 540769-28-6Synonyms: ACT-058362 (Standard)Palosuran (Standard) is the analytical standard of Palosuran. This product is intended for research and analytical applications. Palosuran (ACT-058362) is a potent, selective, and orally active antagonist of urotensin II receptor, with an IC50 of 3.6 nM for CHO cell membranes expressing human recombinant receptors. Palosuran can improves pancreatic and renal function in diabetic rats.
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SB-436811
0 ImagesCat. No.: HY-10666CAS No.: 346729-66-6SB-436811 is a human urotensin-II receptor antagonist with a pKi value of 6.7.
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