2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Branched Chain Amino Acid Transaminase (BCAT)
  5. Branched Chain Amino Acid Transaminase (BCAT) Substrate

Branched Chain Amino Acid Transaminase (BCAT) Substrate

Branched Chain Amino Acid Transaminase (BCAT) Substrate (1):

Cat. No. Product Name Effect Purity
  • HY-W017387
    Sodium α-ketoisocaproate
    		Substrate 98.0%
    Sodium α-ketoisocaproate (Sodium 4-methyl-2-oxopentanoate) is an insulin secretagogue. Sodium α-ketoisocaproate undergoes transamination catalyzed by BCAT and BCATm to produce α-ketoglutarate and leucine; it also binds to the SUR1 site to inhibit KATP channel activity, but does not directly affect the Kir6.2 subunit. Sodium α-ketoisocaproate regulates Ca2+ influx. Sodium α-ketoisocaproate exerts insulinotropic activity in pancreatic islets and intact mouse pancreata with sufficient BCATm expression. Sodium α-ketoisocaproate can be used in research related to type 2 diabetes.