Cuproptosis

Cuproptosis refers to a process in which, under conditions of copper overload, copper ions within cells damage mitochondrial function through a specific mechanism, leading to programmed cell death.

References:

[1]. Wang Y, et al. Cuproptosis: A novel therapeutic target for overcoming cancer drug resistance. Drug Resist Updat. 2024 Jan;72:101018. [Content Brief]

[2]. Tsvetkov P, et al. Copper induces cell death by targeting lipoylated TCA cycle proteins. Science. 2022 Mar 18;375(6586):1254-1261.

Cuproptosis Related Products (21)
Related Compound Screening Libraries (1)
Cuproptosis Signaling Pathway

By Effects:	Inhibitors (6) Inducers (12)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-B0572R

Zinc Pyrithione (Standard)	Inducer
Zinc Pyrithione (Standard) is the analytical standard of Zinc Pyrithione. This product is intended for research and analytical applications. Zinc Pyrithione is an antifungal and antibacterial agent disrupting membrane transport by blocking the proton pump. Zinc Pyrithione is also a copper ionophore that delivers copper into cells and is a useful tool for studying cuproptosis.

Cuproptosis Compound Library

Compound library containing a variety of Cuproptosis related compounds.

403compounds HY-L133

Elesclomol STEAP Metalloreductase SLC31A1 GLUT1,3,
4,12 Glucose Lipoic acid BSO ATP1A
Enterocyte Elesclomol Pyruvate ATOX1 GSH
LA LA LA LA GSH Elesclomol Mitochondrion PDH Npl4 p97 LA LA LA LA DLAT DLAT DLAT DLAT Aggregation TCA Cycle Acetyl-CoA LIAS DLAT Oxidative
Phosphorylation
Cuproptosis Tumor
Suppression TCA Cycle Fe-S Cluster
Destabilization Fe-S
Cluster FDX1 Golgi FDXR ISCU FXN p53 Parkin Bile duct (Export) Hepatocyte (Storage) Blood stream CP CP HSA SLC31A1 ATP1B
Hepatocyte CCS SOD1 MT COX17 ATOX1 COX11 Mitochondrion SCO1 SCO2 CCO p53 Oxidative
Phosphorylation AIF Cuproptosis Nucleus DNA
Breakage ATOX1

Download Cuproptosis Signaling Pathway Map.

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Cuproptosis

Cuproptosis Related Products (21)

Related Compound Screening Libraries (1)

Cuproptosis Signaling Pathway

Cuproptosis Related Products (21):