2. Signaling Pathways
  3. Metabolic Enzyme/Protease
    Neuronal Signaling
  4. Dihydroceramide Desaturase 1 (DES1)
  5. Dihydroceramide Desaturase 1 (DES1) Inhibitor

Dihydroceramide Desaturase 1 (DES1) Inhibitor

Dihydroceramide Desaturase 1 (DES1) Inhibitors (3):

Cat. No. Product Name Effect Purity
  • HY-135818
    XM462
    		Inhibitor 99.80%
    XM462 is a dihydroceramide desaturase inhibitor. XM462 produced a mixed-type inhibition (Ki=2 μM) in vitro. XM462 has dihydroceramide desaturase inhibition both in vitro and in cultured cells with IC50 values of 8.2 and 0.78 μM, respectively. XM462 can be used for the research of tumor.
  • HY-163472
    PR280
    		Inhibitor 98.69%
    PR280 is a dihydroceramide desaturase 1 (Des1) inhibitor with an IC50 of 700 nM. PR280 is used for the research of metabolic diseases, cancers, and neurodegenerative diseases.
  • HY-183723
    GAA-4OH
    		Inhibitor
    GAA-4OH is a potent and irreversible dihydroceramide desaturase-1 (DES1) inhibitor with an IC50 of 0.6 μM and a Ki of 139.5 nM. GAA-4OH undergoes oxidation to form a reactive iminoquinone that covalently blocks DES1’s catalytic cavity, causing permanent enzyme inactivation. GAA-4OH modulates sphingolipid balance by reducing ceramide-to-dihydroceramide ratios in liver tissue. GAA-4OH improves liver steatosis, inflammation, fibrosis, and reduces pro-inflammatory and pro-fibrogenic gene expression. GAA-4OH can be used for the research of metabolic dysfunction-associated steatotic liver disease (MASLD).