2. Signaling Pathways
  3. Immunology/Inflammation
  4. Fc Receptor (FcR)
  5. Fc Receptor (FcR) Modulator

Fc Receptor (FcR) Modulator

Fc Receptor (FcR) Modulator (1):

Cat. No. Product Name Effect Purity
  • HY-P992474
    TAVO101
    		Modulator
    TAVO101 is a humanized anti-TSLP antibody with an EC50 of 0.19 nM against hTSLP. TAVO101 inhibits STAT5 activation and CCL17 release. TAVO101 carries Fc region mutations that enhance its binding to FcRn while reducing its binding to FcγRI, FcγRIIIA and C1q, thereby attenuating effector functions. TAVO101 reduces the levels of inflammatory markers, cell infiltration and histopathological damage in preclinical models of asthma, psoriasis and atopic dermatitis. TAVO101 can be used for research related to asthma, psoriasis and atopic dermatitis.