2. Signaling Pathways
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  4. Fluorescent Dye

Fluorescent Dye

Fluorescence is a phenomenon of photoluminescence in luminescence. When an atom is irradiated by light, some electrons around the nucleus jump from their original orbitals to higher energy orbitals under the influence of light energy, i.e., from the ground state to the first or second excited single-line state, etc. Due to the instability of the first or second excited singlet state, the electron returns from the excited singlet state to the ground state accompanied by released energy, resulting in fluorescence.

Fluorescent dyes can be covalently bound or physically adsorbed in the structure of the substance. The fluorescence properties allow for the characterization, localization and quantitative analysis of the labeled object. Fluorescent dyes have shown great potential for the detection of proteins, nucleic acids, cells, and immunoassays, attributed to the advantages in non-radioactive contamination, simple experimental operation and easy observation.

Fluorescent dyes have penetrated many fields such as pharmacology, physiology, environmental science, and information science, as well as functional studies of proteins and drug screening.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-NP164I
    Concanavalin A-AF546
    Concanavalin A-AF546 (Con A-AF546) is an AF546-labled Concanavalin A (HY-P2149). Concanavalin A is a Ca2+/Mn2+-dependent and mannose/glucose-binding plant lectin. Concanavalin A binds the N- and O-glycosylated proteins of head and neck carcinoma cells glycoproteins.
    Concanavalin A-AF546
  • HY-D1074
    DiOC3(3)
    DiOC3(3) (3,3'-Dipropyloxacarbocyanine iodide) is a green fluorescent lipophilic dye with cell membrane permeability. DiOC3(3) can be used to stain cell membranes and other lipid-soluble biological structures.
    DiOC3(3)
  • HY-D2949
    SNAP-549
    SNAP-549 is a DY-549P1-labeled SNAP tag fluorescent probe, specifically designed for single-molecule imaging and dynamic tracking of proteins in living cells. SNAP-549 only labels SNAP-tag fusion proteins, with low background signals and forming irreversible connections, making it suitable for long-term observation.
    SNAP-549
  • HY-174870
    PROTAC ERα Degrader-11
    PROTAC ERα Degrader-11 is a selective and intrinsically fluorescent (Ex: 366 nm, Em: 440 nm) ERα PROTAC degrader. PROTAC ERα Degrader-11 shows good antiproliferative activity, selective ERα degradation and imaging capabilities in MCF-7 breast cancer cell lines. PROTAC ERα Degrader-11 induces G2/M phase arrest and induces apoptosis in MCF-7 cells. PROTAC ERα Degrader-11 is well-tolerated up to a dose of 500 mg/ kg with no acute toxicity in athymic nude mice. PROTAC ERα Degrader-11 can be used for the study of breast cancer.(Pink: ERα ligand (HY-167701), Blue: CRBN Ligand (HY-150831), Black: Linker, E3 ligase ligand-linker conjugate (HY-174880)).
    PROTAC ERα Degrader-11
  • HY-D2113
    TAMRA-PEG3-Alkyne
    TAMRA-PEG3-Alkyne is a dye derivative of TAMRA (HY-135640) containing 3 PEG units. TAMRA-PEG3-Alkyne contains Alkyne groups and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    TAMRA-PEG3-Alkyne
  • HY-D2004
    ATTO 488 streptavidin
    ATTO 488 streptavidin is a fluorescent reagent that specifically targets and binds to biotin (biotin), formed by the conjugation of ATTO 488 with streptavidin (HY-P3152). ATTO 488 streptavidin enables visualization of the activity of streptavidin immobilized on the surface of polymeric nanoparticles, or acts as a fluorescent probe to detect the selective binding and internalization process of anti-HB-EGF/NA with cells expressing HB-EGF (with no such effect on cells that do not express this receptor). ATTO 488 streptavidin effectively verifies the function of streptavidin conjugated to the surface of nanoparticles and is suitable for research related to atherosclerotic cardiovascular diseases.
    ATTO 488 streptavidin
  • HY-D2847
    FITC-PEG2000-DBCO
    FITC-PEG2000-DBCO is a fluorescent dye composed of FITC (HY-66019), PEG and dibenzocyclooctyne (DBCO). DBCO is a cycloalkyne that can react with molecules containing azide groups through "click chemistry" to achieve coupling (Ex/Em=488/525 nm).
    FITC-PEG2000-DBCO
  • HY-D3416
    TMR-DN
    TMR-DN (TAMRA-2,4-dinitroaniline) is a bright orange fluorescent probe that binds to the SRB-2 aptamer, with a Kd value of 35 nM for the SRB-2 aptamer. TMR-DN exhibits low background fluorescence, enabling wash-free live-cell RNA imaging.
    TMR-DN
  • HY-P3476
    Mca-VDQVDGW-Lys(Dnp)-NH2
    Mca-VDQVDGW-Lys(Dnp)-NH2 is a fluorogenic substrate of caspase-7. Mca-VDQVDGW-K(Dnp)-NH2 can be used to quantify caspase-7 activity.
    Mca-VDQVDGW-Lys(Dnp)-NH2
  • HY-19503
    Omocianine
    Omocianine (Omocyanine) is a fluorescence imaging agent and has the potential to detect malignant breast lesions.
    Omocianine
  • HY-D1551
    10-(4-(Bis(2-hydroxyethyl)amino)phenyl)-5,5-difluoro-1,3,7,9-tetramethyl-5H-dipyrrolo[1,2-c:2',1'-f][1,3,2]diazaborinin-4-ium-5-uide
    10-(4-(Bis(2-hydroxyethyl)amino)phenyl)-5,5-difluoro-1,3,7,9-tetramethyl-5H-dipyrrolo[1,2-c:2',1'-f][1,3,2]diazaborinin-4-ium-5-uide, a BODIPY derivative, is a fluorescent indicator for detecting Pb2+ (Ex=504 nM, Em=510 nM).
    10-(4-(Bis(2-hydroxyethyl)amino)phenyl)-5,5-difluoro-1,3,7,9-tetramethyl-5H-dipyrrolo[1,2-c:2',1'-f][1,3,2]diazaborinin-4-ium-5-uide
  • HY-D3009
    LCE1
    LCE1 is an azacrown ether-based NIR fluorescence probe. LCT can be used for the detection of Pb2+ in food, environmental water, plant and animal samples.
    LCE1
  • HY-159693D
    Cy3 labled ISIS 626112 sodium
    Cy3 labled ISIS 626112 sodium is a Cy3 labled ISIS 626112 sodium.
    Cy3 labled ISIS 626112 sodium
  • HY-147080D
    Cy3 labled Avacincaptad pegol sodium
    Cy3 labled Avacincaptad pegol sodium is a Cy3 labled Avacincaptad pegol sodium.
    Cy3 labled Avacincaptad pegol sodium
  • HY-D2983
    ARHB
    ARHB is a highly selective and sensitive NAT2 fluorescent probe suitable for real-time detection of NAT2 activity in various bacteria. ARHB can successfully penetrate the bacterial cells, and the fluorescence intensity is positively correlated with the expression level of NAT2. ARHB is used for high-throughput screening of natural inhibitors for tuberculosis.
    ARHB
  • HY-D2325
    Arg-Flipper 34
    Arg-Flipper 34 is one of the flipper probes which have been introduced as small molecule fluorophores to image membrane tension in living systems. Arg-Flipper 34 can be used to assess the mechanics of early endocytosis.
    Arg-Flipper 34
  • HY-D1022
    Biotin-16-dUTP
    Biotin-16-dUTP (Biotin-16-deoxyuridine-5'-triphosphate) can be used to replace its natural counterpart dTTP by enzymatically incorporating it into DNA/cDNA. Biotin-16- dUTP can be used to produce biotinylated DNA probes in a variety of assay applications.
    Biotin-16-dUTP
  • HY-D2837
    m-PEG2000-PEI-Cy5
    mPEG-PEI-Cy5 (MW 2000) is a fluorescent dye composed of polyethylene glycol (PEG), FITC (HY-66019) and a Biotin (HY-B0511). mPEG-PEI-Cy5 (MW 2000) can be used for fluorescent labeling and imaging.
    m-PEG2000-PEI-Cy5
  • HY-145624D
    Cy3 labled Obeversen sodium
    Cy3 labled Obeversen sodium is a Cy3 labled Obeversen sodium.
    Cy3 labled Obeversen sodium
  • HY-D2842B
    FITC-PEG2000-biotin
    FITC-PEG2000-biotin is a fluorescent dye composed of polyethylene glycol (PEG), FITC (HY-66019) and a Biotin (HY-B0511). FITC-PEG2000-biotin can be used for fluorescent labeling and imaging.
    FITC-PEG2000-biotin
Cat. No. Product Name / Synonyms Application Reactivity