2. Signaling Pathways
  3. Immunology/Inflammation
  4. IKZF Family
  5. IKZF1 Isoform
  6. IKZF1 Inhibitor

IKZF1 Inhibitor

IKZF1 Inhibitors (2):

Cat. No. Product Name Effect Purity
  • HY-145776
    ALV1
    		Inhibitor 98.62%
    ALV1 is a molecular glue degrader for Ikaros (IKZF1) and Helios (IKZF2) with DC50 of 2.5 nM and 10.3 nM respectively. ALV1 bind CRBN with an IC50 of 0.55 μM, and induces CRBN-Helios dimerization. ALV1 can be used to study the properties and functions of regulatory T cells.
  • HY-181651
    SZU305
    		Inhibitor
    SZU305 is a RAD51 PROTAC degrader, with DC50 values of 307.45 nM and 84.19 nM in SK-HEP-1 and Huh-7 cells, respectively. SZU305 inhibits DNA damage repair, induces cell cycle arrest and apoptosis. SZU305 moderately reduces the protein levels of IKZF1 and IKZF3 at high concentrations. SZU305 can be used in studies related to hepatocellular carcinoma.