2438124-79-7
2438124-79-7
Chemical Structure
ALV1
- CAS No.: 2438124-79-7
- Formula:C25H23ClN4O5
- Molecular Weight:494.93
IUPAC Name: N-(3-chloro-4-methylphenyl)-3-(3-((1-(2,6-dioxopiperidin-3-yl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl)amino)phenyl)propanamide
InChIKey: YDYSAFPHVGVORZ-UHFFFAOYSA-N
SMILES: O=C(NC1=CC=C(C)C(Cl)=C1)CCC2=CC=CC(NC3=CC(N(C(CC4)C(NC4=O)=O)C3=O)=O)=C2
Biological Activity: ALV1 is a molecular glue degrader for Ikaros (IKZF1) and Helios (IKZF2) with DC50 of 2.5 nM and 10.3 nM respectively. ALV1 bind CRBN with an IC50 of 0.55 μM, and induces CRBN-Helios dimerization. ALV1 can be used to study the properties and functions of regulatory T cells[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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ALV1 | 98.62% | ALV1 is a molecular glue degrader for Ikaros (IKZF1) and Helios (IKZF2) with DC50 of 2.5 nM and 10.3 nM respectively. ALV1 bind CRBN with an IC50 of 0.55 μM, and induces CRBN-Helios dimerization. ALV1 can be used to study the properties and functions of regulatory T cells. | ||||||||||||||||||||
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