SMARCA2 Inhibitor
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FHD-909
0 ImagesCat. No.: HY-185075CAS No.: 3008577-34-9Synonyms: LY4050784FHD-909 (LY4050784) is an orally active and selective SMARCA2 (BRM) ATPase inhibitor. FHD-909 potently inhibits purified BRM ATPase with an IC50 of 0.0025 μM and exhibits 35.69-fold selectivity for BRM over purified SMARCA4 (BRG1) ATPase. FHD-909 induces synthetic lethality, suppresses cell proliferation, modulates target gene expression, and achieves remarkable tumor growth inhibition and regression in SMARCA4-mutant cancer cells and xenograft models. FHD-909 can be used for the research of SMARCA4/BRG1-mutant cancers, advanced solid tumors, and BAF complex-related disorders.
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PROTAC SMARCA2 degrader-31
0 ImagesCat. No.: HY-168234CAS No.: 2380274-45-1PROTAC SMARCA2-degrader-36 is a PROTAC degrader of SMARCA2, achieving a 99% degradation rate in H929 cells. It also exhibits degradative activity against SMARCA4, but with relatively weaker efficacy. PROTAC SMARCA2-degrader-36 can inhibit cancer cell proliferation and may be used in research related to multiple myeloma.
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SMARCA2/4-IN-4
0 ImagesCat. No.: HY-161885CAS No.: 2270875-79-9SMARCA2-IN-6 is a SMARCA2 and SMARCA4 inhibitor, with an IC50 value of <0.005 μM for both SMARCA2 and SMARCA4. SMARCA2-IN-6 exerts anticancer activity against BRG1-mutant melanoma. SMARCA2-IN-6 can be used for research related to Brg1/Smarca4-mutant cancers.
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SMI-1074
0 ImagesCat. No.: HY-170817CAS No.: 3033592-13-8
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SMARCA2/4-ligand-1
0 ImagesCat. No.: HY-159472CAS No.: 2411651-36-82-(6-Amino-5-(1-(piperidin-4-ylmethyl)-1H-pyrazol-4-yl)pyridazin-3-yl)phenol is a Ligand for target protein for pROTAC.
