1. Signaling Pathways
  2. Membrane Transporter/Ion Channel
  3. Urea Transporter
  4. Urea Transporter Inhibitor

Urea Transporter Inhibitor

Urea Transporter Inhibitors (3):

Cat. No. Product Name Effect Purity
  • HY-128129
    UT-B-IN-1
    Inhibitor 99.68%
    UT-B-IN-1 (UTBINH-14) is a reversible, competitive and selective urea transporter-B (UT-B) inhibitor with IC50 values of 10 and 25 nM for human and mouse UT-B, respectively. UT-B-IN-1 shows low toxicity and high selectivity for UT-B over UT-A isoforms. UT-B-IN-1 increases urine output and reduces urine osmolality of mice. UT-B-IN-1 can be used for diuretic mechanism research.
  • HY-155642
    PU-48
    Inhibitor 99.64%
    PU-48 is a potent urea transporters A (UT-A) inhibitor (IC50=0.32 μM). PU-48 has a good diuretic effect in mouse models, and shows little or no cytotoxicity. PU-48 has the potential to be developed as a diuretic.
  • HY-131382
    UTA1inh-C1
    Inhibitor
    UTA1inh-C1 is a urea transporter (UT-A) inhibitor with IC50 of 4.2 μM.