2. Signaling Pathways
  3. Membrane Transporter/Ion Channel
  4. Urea Transporter
  5. Urea Transporter Inhibitor

Urea Transporter Inhibitor

Urea Transporter Inhibitors (8):

Cat. No. Product Name Effect Purity
  • HY-155642
    PU-48
    		Inhibitor 99.76%
    PU-48 is a potent urea transporters A (UT-A) inhibitor (IC50=0.32 μM). PU-48 has a good diuretic effect in mouse models, and shows little or no cytotoxicity. PU-48 has the potential to be developed as a diuretic.
  • HY-128129
    UT-B-IN-1
    		Inhibitor 99.68%
    UT-B-IN-1 (UTBINH-14) is a reversible, competitive and selective urea transporter-B (UT-B) inhibitor with IC50 values of 10 and 25 nM for human and mouse UT-B, respectively. UT-B-IN-1 shows low toxicity and high selectivity for UT-B over UT-A isoforms. UT-B-IN-1 increases urine output and reduces urine osmolality of mice. UT-B-IN-1 can be used for diuretic mechanism research.
  • HY-183637
    E822-1968
    		Inhibitor
    E822-1968 is an UT-A2 inhibitor with a human IC50 of 0.44 μM. E822-1968 blocks urea transport mediated by UT-A2. E822-1968 can be used for the study of hyponatremia and edema associated with congestive heart failure, nephrotic syndrome, and cirrhosis.
  • HY-183636
    M353-0039
    		Inhibitor
    M353-0039 is a selective UT-A2 inhibitor with a human IC50 of 0.35 μM. M353-0039 blocks urea transport mediated by UT-A2. M353-0039 can be used for the study of hyponatremia and edema associated with congestive heart failure, nephrotic syndrome, and cirrhosis.
  • HY-121132
    Butibufen
    		Inhibitor
    Butibufen is an orally active non-steroidal compound. Butibufen shows analgesic and antipyretic properties. Butibufen can be used for the research of inflammation.
  • HY-116718
    UTA1inh-D1
    		Inhibitor
    UTA1inh-D1 is a selective UT-A1 and UT-B urea transporter inhibitor with IC50 values of 3.8 μM and 15 μM, respectively. UTA1inh-D1 is promising for research of refractory edema, such as congestive heart failure and cirrhosis.
  • HY-124107
    UTA1inh-A1
    		Inhibitor
    UTA1inh-A1 is a urea transporter (UT) inhibitor. UTA1inh-A1 has IC50 values of 3.3 μM and 16 μM for UT-A1 and UT-B. UTA1inh-A1 can be used in research related to urearetics.
  • HY-131382
    UTA1inh-C1
    		Inhibitor
    UTA1inh-C1 is a urea transporter (UT-A) inhibitor with IC50 of 4.2 μM.