Urea Transporter Inhibitor
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PU-48
0 ImagesPU-48 is a blood-brain barrier-permeable urea transporter (UT) inhibitor with an IC50 of 0.32 μM against rat UT-A. By functionally inhibiting urea transporters (including UT-A subtypes) in the renal inner medullary collecting ducts, PU-48 induces urea-selective diuresis. PU-48 does not alter blood levels of sodium, potassium or chloride ions, nor does it affect the excretion of non-urea solutes. PU-48 shows no significant toxicity in cell or animal models and can be used in edema-related research.
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UT-B-IN-1
0 ImagesUT-B-IN-1 (UTBINH-14) is a reversible, competitive and selective urea transporter-B (UT-B) inhibitor with IC50 values of 10 and 25 nM for human and mouse UT-B, respectively. UT-B-IN-1 shows low toxicity and high selectivity for UT-B over UT-A isoforms. UT-B-IN-1 increases urine output and reduces urine osmolality of mice. UT-B-IN-1 can be used for diuretic mechanism research.
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E822-1968
0 ImagesCat. No.: HY-183637CAS No.: 1037259-63-4E822-1968 is an UT-A2 inhibitor with a human IC50 of 0.44 μM. E822-1968 blocks urea transport mediated by UT-A2. E822-1968 can be used for the study of hyponatremia and edema associated with congestive heart failure, nephrotic syndrome, and cirrhosis.
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M353-0039
0 ImagesCat. No.: HY-183636CAS No.: 1185074-29-6M353-0039 is a selective UT-A2 inhibitor with a human IC50 of 0.35 μM. M353-0039 blocks urea transport mediated by UT-A2. M353-0039 can be used for the study of hyponatremia and edema associated with congestive heart failure, nephrotic syndrome, and cirrhosis.
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Butibufen
0 ImagesButibufen is an orally active non-steroidal compound. Butibufen shows analgesic and antipyretic properties. Butibufen can be used for the research of inflammation.
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UTA1inh-D1
0 ImagesCat. No.: HY-116718CAS No.: 892745-28-7UTA1inh-D1 is a selective UT-A1 and UT-B urea transporter inhibitor with IC50 values of 3.8 μM and 15 μM, respectively. UTA1inh-D1 is promising for research of refractory edema, such as congestive heart failure and cirrhosis.
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UTA1inh-A1
0 ImagesCat. No.: HY-124107CAS No.: 1251688-22-8UTA1inh-A1 is a urea transporter (UT) inhibitor. UTA1inh-A1 has IC50 values of 3.3 μM and 16 μM for UT-A1 and UT-B. UTA1inh-A1 can be used in research related to urearetics.
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UTA1inh-C1
0 ImagesCat. No.: HY-131382CAS No.: 332144-37-3UTA1inh-C1 is a urea transporter (UT-A) inhibitor with IC50 of 4.2 μM.
