AF-DX 384 methanesulfonate
AF-DX 384 (methanesulfonate) is a selective antagonist of M2 and M4 muscarinic acetylcholine receptors (Kis=6.03 and 10 nM, respectively). AF-DX 384 (methanesulfonate) reverses deficits in novel object recognition and passive avoidance in aged rats, as well as in young rats with impairments induced by scopolamine.
For research use only. We do not sell to patients.
- CAS No.: 118290-27-0
- Formula: C28H42N6O5S
- Molecular Weight:574.74
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Chemical Information
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CAS No. 118290-27-0
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Molecular Weight 574.74
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Formula C28H42N6O5S
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SMILES
O=C(N1C2=NC=CC=C2NC(C3=CC=CC=C31)=O)NCCN4C(CN(CCC)CCC)CCCC4.CS(=O)(O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Dörje F, et al. Antagonist binding profiles of five cloned human muscarinic receptor subtypes. J Pharmacol Exp Ther. 1991 Feb;256(2):727-33. [Content Brief]
[2]. Vannucchi MG, et al. Selective muscarinic antagonists differentially affect in vivo acetylcholine release and memory performances of young and aged rats. Neuroscience. 1997 Aug;79(3):837-46. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AF-DX 384 methanesulfonate Related Classifications
HY-124223 Related Classifications
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