118290-27-0
Chemical Structure
AF-DX 384 methanesulfonate
- CAS No.: 118290-27-0
- Formula:C28H42N6O5S
- Molecular Weight:574.74
IUPAC Name: N-(2-(2-((dipropylamino)methyl)piperidin-1-yl)ethyl)-6-oxo-5,6-dihydro-11H-benzo[e]pyrido[3,2-b][1,4]diazepine-11-carboxamide methanesulfonate
InChIKey: LBXOPAJGAXATCZ-UHFFFAOYSA-N
SMILES: O=C(N1C2=NC=CC=C2NC(C3=CC=CC=C31)=O)NCCN4C(CN(CCC)CCC)CCCC4.CS(=O)(O)=O
Biological Activity: AF-DX 384 (methanesulfonate) is a selective antagonist of M2 and M4 muscarinic acetylcholine receptors (Kis=6.03 and 10 nM, respectively)[1]. AF-DX 384 (methanesulfonate) reverses deficits in novel object recognition and passive avoidance in aged rats, as well as in young rats with impairments induced by scopolamine[2].
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AF-DX 384 methanesulfonate | AF-DX 384 (methanesulfonate) is a selective antagonist of M2 and M4 muscarinic acetylcholine receptors (Kis=6.03 and 10 nM, respectively). AF-DX 384 (methanesulfonate) reverses deficits in novel object recognition and passive avoidance in aged rats, as well as in young rats with impairments induced by scopolamine. | |||||||||||||||||||||
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- [1]. Dörje F, et al. Antagonist binding profiles of five cloned human muscarinic receptor subtypes. J Pharmacol Exp Ther. 1991 Feb;256(2):727-33. [Content Brief]
- [2]. Vannucchi MG, et al. Selective muscarinic antagonists differentially affect in vivo acetylcholine release and memory performances of young and aged rats. Neuroscience. 1997 Aug;79(3):837-46. [Content Brief]
Keywords
