Alclometasone dipropionate
Alclometasone dipropionate (Sch 22219) is a steroid compound. Alclometasone dipropionate can be used for the research of dermatitis and skin itch.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- CAS. Nr.: 66734-13-2
- Formel: C28H37ClO7
- Molecular Weight:521.04
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Speicherung:Pure form -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
Alclometasone dipropionate (0.01-100 ng/mL; 24 h) suppresses cytokine production of CD3/CD2 stimulation with IC50s of 5.54, 1.76, 2.09, 0.89, 3.26 and 0.76 ng/mL for IL-2, IL-3, IL-4, IL-5, IFN-γ and GM-CSF, respectively in human PBMC[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Lewis rats with tuberculin-induced delayed allergic reaction[2]
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Dosage:0.1% (20 μL)
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Administration:Both sides of the ears; 0.1% (20 μL) 3 h before and 2 h after tuberculin challenge
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Result:Partially inhibited the increase in amount of dye leaked.
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Animal Model:Brown-Norway rats with egg albumin-induced passive cutaneous anaphylaxis reaction[2]
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Dosage:0.1% (20 μL)
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Administration:Both sides of the ears; 0.1% (20 μL) 6 h before egg albumin challenge
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Result:Significantly suppressed the increase in amount of dye leaked in this passive cutaneous anaphylaxis reaction.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS. Nr. 66734-13-2
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Appearance Liquid (Density: 1.0766g/cm³)
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Molecular Weight 521.04
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Formel C28H37ClO7
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Color Colorless to light yellow
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SMILES
CCC(OCC([C@@]1([C@@]2([C@@]([C@@]3([H])[C@]([C@@]4(C(C[C@H]3Cl)=CC(C=C4)=O)C)([H])[C@H](C2)O)([H])C[C@H]1C)C)OC(CC)=O)=O)=O
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Synonyms
Sch 22219
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Pure form -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Reinheit & Dokumentation
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Data Sheet (275 KB)
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SDS (419 KB)
- English - EN (419 KB)
- Français - FR (419 KB)
- Deutsch - DE (419 KB)
- Norwegian - NO (419 KB)
- Español - ES (419 KB)
- Swedish - SV (419 KB)
- Italian - IT (419 KB)
- Korean - KR (419 KB)
- Portuguese - PT (419 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Sakuma S, et al. Tacrolimus suppressed the production of cytokines involved in atopic dermatitis by direct stimulation of human PBMC system. (Comparison with steroids). Int Immunopharmacol. 2001 Jun;1(6):1219-26. [Content Brief]
[2]. Sengoku T, et al. Possible inhibitory mechanism of FK506 (tacrolimus hydrate) ointment for atopic dermatitis based on animal models. Eur J Pharmacol. 1999 Aug 27;379(2-3):183-9. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Alclometasone dipropionate Related Classifications
HY-106566 Related Classifications
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