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Alclometasone dipropionate  (Synonyms: Sch 22219)

Cat. No.: HY-106566
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Alclometasone dipropionate (Sch 22219) is a steroid compound. Alclometasone dipropionate can be used for the research of dermatitis and skin itch.

For research use only. We do not sell to patients.

Alclometasone dipropionate Chemical Structure

Alclometasone dipropionate Chemical Structure

CAS No. : 66734-13-2

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2500 μg USD 158 In-stock

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Based on 1 publication(s) in Google Scholar

Alclometasone dipropionate Related Antibodies

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Description

Alclometasone dipropionate (Sch 22219) is a steroid compound. Alclometasone dipropionate can be used for the research of dermatitis and skin itch[1][2].

In Vitro

Alclometasone dipropionate (0.01-100 ng/mL; 24 h) suppresses cytokine production of CD3/CD2 stimulation with IC50s of 5.54, 1.76, 2.09, 0.89, 3.26 and 0.76 ng/mL for IL-2, IL-3, IL-4, IL-5, IFN-γ and GM-CSF, respectively in human PBMC[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Alclometasone dipropionate Related Antibodies
In Vivo

Alclometasone dipropionate (0.1% (20 μL); both sides of the ears; once) shows effects on tuberculin- and egg albumin-induced allergic reaction[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Lewis rats with tuberculin-induced delayed allergic reaction[2]
Dosage: 0.1% (20 μL)
Administration: Both sides of the ears; 0.1% (20 μL) 3 h before and 2 h after tuberculin challenge
Result: Partially inhibited the increase in amount of dye leaked.
Animal Model: Brown-Norway rats with egg albumin-induced passive cutaneous anaphylaxis reaction[2]
Dosage: 0.1% (20 μL)
Administration: Both sides of the ears; 0.1% (20 μL) 6 h before egg albumin challenge
Result: Significantly suppressed the increase in amount of dye leaked in this passive cutaneous anaphylaxis reaction.
Clinical Trial
Molecular Weight

521.04

Formula

C28H37ClO7
CAS No.
SMILES

CCC(OCC([C@@]1([C@@]2([C@@]([C@@]3([H])[C@]([C@@]4(C(C[C@H]3Cl)=CC(C=C4)=O)C)([H])[C@H](C2)O)([H])C[C@H]1C)C)OC(CC)=O)=O)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Alclometasone dipropionate Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Alclometasone66734-13-2Sch 22219Sch22219Sch-22219OtherssteroidcytokinePBMCtuberculinegg albuminallergic reactionInhibitorinhibitorinhibit

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