1. Cell Cycle/DNA Damage
    Apoptosis
  2. CDK
    Apoptosis
  3. Aminopurvalanol A

Aminopurvalanol A 

Cat. No.: HY-104013 Purity: 98.00%
Handling Instructions

Aminopurvalanol A is a potent, selective, and cell permeable inhibitor of Cyclins/Cdk complexes. Aminopurvalanol A preferentially targets the G2/M-phase transition inhibiting cancer cell differentiation. Aminopurvalanol A causes the inhibition of sperm fertilizing ability via the inhibition of physiological capacitation-dependent actin polymerization.

For research use only. We do not sell to patients.

Aminopurvalanol A Chemical Structure

Aminopurvalanol A Chemical Structure

CAS No. : 220792-57-4

Size Price Stock Quantity
5 mg USD 120 In-stock
Estimated Time of Arrival: December 31
10 mg USD 200 In-stock
Estimated Time of Arrival: December 31
25 mg USD 390 In-stock
Estimated Time of Arrival: December 31
50 mg USD 600 In-stock
Estimated Time of Arrival: December 31
100 mg USD 900 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Aminopurvalanol A is a potent, selective, and cell permeable inhibitor of Cyclins/Cdk complexes. Aminopurvalanol A preferentially targets the G2/M-phase transition inhibiting cancer cell differentiation. Aminopurvalanol A causes the inhibition of sperm fertilizing ability via the inhibition of physiological capacitation-dependent actin polymerization[1][2].

IC50 & Target

Cyclins/Cdk[1]

In Vitro

Aminopurvalanol A (5 and 40 μM; 8 hours) inhibits cell growth primarily by arresting the cells in the G2 phase of the cell cycle and, at higher concentration, triggering apoptosis[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cycle Analysis[2]

Cell Line: Human U937 leukemic cells
Concentration: 5 and 40 μM
Incubation Time: 8 hours
Result: Increased the number of cells with a 4N DNA content as early as 8 h after the beginning of treatment at 5 μM. 40 μM led to cellular fragmentation and cells with an irregular DNA distribution, characteristic of apoptotic cell populations.

Apoptosis Analysis[2]

Cell Line: Human U937 leukemic cells
Concentration: 5 and 40 μM
Incubation Time: 8 hours
Result: 40 μM Aminopurvalanol A led to apoptosis rather than after the beginning of treatment at 5 μM.
Molecular Weight

403.91

Formula

C19H26ClN7O

CAS No.
SMILES

CC(C)N1C2=NC(N[[email protected]@H](CO)C(C)C)=NC(NC3=CC(Cl)=CC(N)=C3)=C2N=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (247.58 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4758 mL 12.3790 mL 24.7580 mL
5 mM 0.4952 mL 2.4758 mL 4.9516 mL
10 mM 0.2476 mL 1.2379 mL 2.4758 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (6.19 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (6.19 mM); Clear solution

*All of the co-solvents are available by MCE.
References
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Product Name:
Aminopurvalanol A
Cat. No.:
HY-104013
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