Androgen receptor antagonist 7
Androgen receptor antagonist 7 is an effective androgen receptor (AR) antagonist with an IC50 value of 1.18 µM. Androgen receptor antagonist 7 has biological activity in vitro and inhibits the expression of AR target in a time and dose dependent manner with an GI50 value of 7.9 µM .
For research use only. We do not sell to patients.
- CAS No.: 2409791-89-3
- Formula: C27H35FN2O
- Molecular Weight:422.58
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
IC50: 1.18 µM[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| LAPC4 | GI50 |
7.9 μM
Compound: 3d
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Antiproliferative activity against human LAPC4 cells
Antiproliferative activity against human LAPC4 cells
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[PMID: 36682291] |
Androgen receptor antagonist 7 (compound 3d) (10 µM; 24 h) significantly reduces the expression level of AR protein[1].
Androgen receptor antagonist 7 (20 µM; 72 h) inhibits the proliferation of LAPC-4 and 22Rv1 cells[1].
Androgen receptor antagonist 7 (0-20 µM; 24, 48 and 72 h) inhibits the expression of AR in a time and dose dependent manner without inducing apoptosis[1].
Androgen receptor antagonist 7 (10 µM; 3 d) targets AR in vitro and reduces the expression of AR[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:LAPC-4 cell.
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Concentration:0-20 µM.
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Incubation Time:24, 48 and 72 h.
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Result:Showed inhibitory effect.
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Cell Line:LAPC-4 and 22Rv1 cells.
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Concentration:20 µM.
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Incubation Time:72 h.
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Result:Showed antiproliferative effect (cell viability < 40 %).
Chemical Information
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CAS No. 2409791-89-3
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Molecular Weight 422.58
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Formula C27H35FN2O
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SMILES
[H][C@@]12CC[C@]3([C@@]4(CC[C@@H]([C@]4(CC[C@@]3([C@]1(CC5=C(N(N=C5C2)C6=CC=C(C=C6)F)C)C)[H])C)O)[H])[H]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Androgen receptor antagonist 7 Related Classifications
HY-152524 Related Classifications
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