2. Metabolic Enzyme/Protease
  3. PAI-1
  4. Anecortave acetate

Anecortave acetate  (Synonyms: Anecortave)

Cat. No.: HY-116868 Purity: ≥99.0%
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Anecortave acetate is a potent ocular angiostatic agent. Anecortave acetate inhibits neovascularization which is induced by many different angiogenic factors, and increases plasminogen activator inhibitor-1 (PAI-1) mRNA expression. Anecortave acetate can be used to research ocular neovascular diseases.

For research use only. We do not sell to patients.

Anecortave acetate Chemical Structure

Anecortave acetate Chemical Structure

CAS No. : 7753-60-8

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10 mg USD 325 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Anecortave acetate is a potent ocular angiostatic agent. Anecortave acetate inhibits neovascularization which is induced by many different angiogenic factors, and increases plasminogen activator inhibitor-1 (PAI-1) mRNA expression. Anecortave acetate can be used to research ocular neovascular diseases[1][2].

IC50 & Target

PAI-1[2]
In Vivo

Anecortave acetate (5 μl of a 10% suspension; Injected into eyes) significantly inhibits pathologic retinal angiogenesis and increases PAI-1 mRNA levels[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague-Dawley albino rats (intravitreally injected with premixed antibiotics to influence retinal vessel growth)[2]
Dosage: 5 μl of a 10% suspension of Anecortave acetate
Administration: Injected into eyes
Result: significantly inhibited pathologic retinal angiogenesis in this model, while not significantly affecting normal intraretinal vessels.
Increased 6-to-9-fold PAI-1 mRNA at 1 to 3 days after injection.
Clinical Trial
Molecular Weight

386.48

Formula

C23H30O5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C[C@@]12[C@](O)(CC[C@]1([C@@]3(CCC4=CC(CC[C@@]4(C3=CC2)C)=O)[H])[H])C(COC(C)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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Anecortave acetate Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anecortave7753-60-8PAI-1Plasminogen activator inhibitor-1ocularneovascularizationangiogenicneovascular diseasesInhibitorinhibitorinhibit

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