1. Metabolic Enzyme/Protease
  2. PAI-1
  3. Diaplasinin

Diaplasinin (Synonyms: PAI-749)

Cat. No.: HY-122098
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Diaplasinin (PAI-749) is a plasminogen activator inhibitor-1 (PAI-1) inhibitor with IC50 of 295 nm. Antithrombotic efficacy.

For research use only. We do not sell to patients.

Diaplasinin Chemical Structure

Diaplasinin Chemical Structure

CAS No. : 481631-45-2

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Description

Diaplasinin (PAI-749) is a plasminogen activator inhibitor-1 (PAI-1) inhibitor with IC50 of 295 nm. Antithrombotic efficacy[1].

In Vitro

PAI-749 is a potent and selective synthetic antagonist of plasminogen activator inhibitor 1 (PAI-1) that preserved tissue-type plasminogen activator (tPA) and urokinase-type plasminogen activator (uPA) activities in the presence of PAI-1 (IC50 values, 157 and 87 nM, respectively)[2].
PAI-749 quenches the fluorescence (Fl) of fluorophore-tagged PAI-1 (PAI-NBD119) with the apparent Kd of 254 nM) and the IC50 of 140 nM[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

501.62

Formula

C₃₂H₃₁N₅O

CAS No.
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Please store the product under the recommended conditions in the Certificate of Analysis.

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Diaplasinin
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