1. Metabolic Enzyme/Protease
  2. PAI-1
  3. UK-371804


Cat. No.: HY-101214 Purity: >98.0%
Handling Instructions

UK-371804 is a urokinase-type plasminogen activator (uPA) inhibitor with a Ki of 10 nM.

For research use only. We do not sell to patients.

UK-371804 Chemical Structure

UK-371804 Chemical Structure

CAS No. : 256477-09-5

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 158 In-stock
Estimated Time of Arrival: December 31
5 mg USD 144 In-stock
Estimated Time of Arrival: December 31
10 mg USD 252 In-stock
Estimated Time of Arrival: December 31
50 mg USD 780 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1140 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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UK-371804 is a urokinase-type plasminogen activator (uPA) inhibitor with a Ki of 10 nM.

IC50 & Target

Ki: 10 nM (uPA)[1]

In Vitro

UK-371804 is able to inhibit exogenous uPA in human chronic wound fluid (IC50=0.89 μM). UK-371804 has its excellent enzyme potency (Ki=10 nM) and selectivity profile (4000-fold versus tPA and 2700-fold versus plasmin)[1].

In Vivo

In a porcine acute excisional wound model, following topical delivery, UK-371804 is able to penetrate into pig wounds and inhibit exogenous uPA activity with no adverse effect on wound healing parameters. Concentrations of UK-371804 in the dermis are 41.8 μM[1].

Molecular Weight









Room temperature in continental US; may vary elsewhere.

Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 8.33 mg/mL (21.59 mM; Need ultrasonic)

Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5918 mL 12.9591 mL 25.9182 mL
5 mM 0.5184 mL 2.5918 mL 5.1836 mL
10 mM 0.2592 mL 1.2959 mL 2.5918 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 0.83 mg/mL (2.15 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 0.83 mg/mL (2.15 mM); Clear solution

*All of the co-solvents are provided by MCE.
Animal Administration

Pigs: Two female pigs are subjected to eight excisional wounds. The wounds are dressed and treated daily for 10 days with either 1 mL of a 10 mg/mL formulation of UK-371804 in hydrogel vehicle, or hydrogel vehicle alone (control). On day 11 the animals are sacrificed, terminal blood samples are taken to assess any systemic exposure of the compounds, and the wounds are excised from the surrounding normal skin[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

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UK-371804UK371804UK 371804PAI-1Plasminogen activator inhibitor-1Inhibitorinhibitorinhibit

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