Anti-Mouse CD172a Antibody (P84) 

Anti-Mouse CD172a Antibody (P84) is a rat-derived anti-mouse CD172a IgG1 κ type antibody inhibitor. Anti-Mouse CD172a Antibody (P84) blocks CD47-SIRPα interaction and thereby augments cell phagocytosis. Anti-Mouse CD172a Antibody (P84) can be used for the researches of infection and immunology, such as salmonella typhimurium infection^[1][2][3].

Rat IgG1 kappa

Rat IgG1 kappa, Isotype Control

Mouse

CD172a

Anti-Mouse CD172a Antibody (P84) (20 mins) significantly increases the engulfment of WT mouse RBCs^[1].
Anti-Mouse CD172a Antibody (P84) (5 μg/mL, 30 mins) enhances the phagocytic incorporation of salmonella typhimurium into Nr2f6-deficient macrophages in splenocytes^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse CD172a Antibody (P84) (100 μg, i.p., one day prior to infection and at days 1 and 2 post-infection) results in weight loss and bacterial counts increase in Nr2f6-deficient mice infected by salmonella typhimurium^[2].
Anti-Mouse CD172a Antibody (P84) (i.p., 24 h before cells injection) prevents the effects of mouse CD47 on macrophage-mediated xenograft rejection in diabetic Rag22/2 c chain 2/2 mice^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

19261  [NCBI]

P97797

in vivo SIRPα blocking; In vitro SIRPα blocking; Western blot; Immunoprecipitation; Flow cytomet

Unconjugated

The product can be reconstituted/diluted with sterile PBS or saline.

150 kDa

Liquid

Colorless to light yellow

[Anti-Mouse CD172a Antibody (P84)]

Please refer to the lot-specific COA for specific buffer information.

Please store the product under the recommended conditions in the Certificate of Analysis.

• 
  Immobilized SIRP alpha/CD172a Protein, Mouse (HEK293, His, HY-P72468) can bind Anti-Mouse CD172a Antibody (P84). The EC₅₀ for this effect is 99.62 ng/mL.

• [1]. Wang H, et al. Attenuation of phagocytosis of xenogeneic cells by manipulating CD47. Blood. 2007 Jan 15;109(2):836-42.  [Content Brief]

  [2]. Woelk J, et al. Loss of NR2F6 Protects from Salmonella Typhimurium Infection. Adv Sci (Weinh). 2025 Jul 2:e04280.  [Content Brief]

  [3]. eraoka Y, et al. Expression of recipient CD47 on rat insulinoma cell xenografts prevents macrophage-mediated rejection through SIRPα inhibitory signaling in mice. PLoS One. 2013;8(3):e58359.  [Content Brief]