Anti-Mouse IL-1R Antibody (JAMA-147)
Based on 1 Customer Validation
Anti-Mouse IL-1R Antibody (JAMA-147) is an anti-mouse IL-1R IgG2b antibody inhibitor derived from host Armenian Hamster. Anti-Mouse IL-1R Antibody (JAMA-147) diminishes Spp1hi-TAM-mediated T cell suppression. Anti-Mouse IL-1R Antibody (JAMA-147) can be used for the researches of inflammation, metabolic disease and infection, such as diabetes.
For research use only. We do not sell to patients.
- Purity : 95.00%
- Molecular Weight:150 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Isotype
Armenian Hamster IgG
Recommend Isotype Controls
Species Reactivity
Mouse
IC50 & Target
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IL-1 |
In Vitro
In Vivo
Anti-Mouse IL-1R Antibody (JAMA-147) (50 μg/kg, i.p., daily for 4 weeks) improves IFNAR signaling in late prediabetic 8 to 10-week-old NOD (non-obese diabetic) mice models[3].
Anti-Mouse IL-1R Antibody (JAMA-147) (40 mg/kg, i.p.) enhances NMEC (neonatal meningitis-causing Escherichia coli) RS218 colonization of the brain, blood and other tissues in NOS2-/- mice[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Experimental autoimmune prostatitis (EAP) mice models (NOD, male, 5 weeks)[1]
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Dosage:200 µg/dose
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Administration:Intraperitoneally injection, every 3 days from day 14 to 28
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Result:Decreased T17 cells and 17+Treg cells and increased Treg cells.
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Animal Model:NOD (non-obese diabetic) mice models (female, 8-10 weeks)[3]
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Dosage:50 μg/kg
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Administration:Intraperitoneally injection, daily for 4 weeks
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Result:Increased expression of tonic-sensitive Irf7, Ifit1, Mx1, Stat1, and Stat2 in the spleen.
Gene ID
Accession
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
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Product Image
Application
in vivo IL-1 R blockade; in vitro IL-1 R blockade
Chemical Information
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Appearance Liquid
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Molecular Weight 150 kDa
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Color Colorless to light yellow
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SMILES
[Anti-Mouse IL-1R Antibody (JAMA-147)]
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (261 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
[1]. Liu X, et al. NLRP3-mediated IL-1β in regulating the imbalance between Th17 and Treg in experimental autoimmune prostatitis. Sci Rep. 2024 Aug 13;14(1):18829. [Content Brief]
[2]. Lyu A, et al. Evolution of myeloid-mediated immunotherapy resistance in prostate cancer. Nature. 2025 Jan;637(8048):1207-1217. [Content Brief]
[3]. Rahman MJ, et al. Restoration of the type I IFN-IL-1 balance through targeted blockade of PTGER4 inhibits autoimmunity in NOD mice. JCI Insight. 2018 Feb 8;3(3):e97843. [Content Brief]
[4]. Chambers CA, et al. Nitric oxide inhibits interleukin-1-mediated protection against Escherichia coli K1-induced sepsis and meningitis in a neonatal murine model. Immunol Cell Biol. 2021 Jul;99(6):596-610. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anti-Mouse IL-1R Antibody (JAMA-147) Related Classifications
HY-P99140 Related Classifications
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