Il1r1 - interleukin 1 receptor, type I Gene

Also Known as IL-iR; CD121a; CD121b; IL-1R1; Il1r-1; IL-1R-1; IL-1RT1; IL-1RT-1; IL-1R-alpha

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16177

Summary

Enables interleukin-1 binding activity; interleukin-1 receptor activity; and protease binding activity. Involved in interleukin-1-mediated signaling pathway. Acts upstream of or within several processes, including cytokine-mediated signaling pathway; positive regulation of interleukin-1-mediated signaling pathway; and positive regulation of neutrophil extravasation. Located in external side of plasma membrane. Is expressed in brain; dorsal aorta; liver; reproductive system; and spleen. Used to study type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in systemic scleroderma and type 1 diabetes mellitus. Orthologous to human IL1R1 (interleukin 1 receptor type 1). [provided by Alliance of Genome Resources, Apr 2022]

Il1r1 Products (4)

mRNA Protein Name
NM_001123382.2 NP_001116854.1 interleukin-1 receptor type 1 isoform 2 precursor
NM_008362.3 NP_032388.1 interleukin-1 receptor type 1 isoform 1 precursor
NM_001123382.2 NP_001116854.1 interleukin-1 receptor type 1 isoform 2 precursor
NM_008362.3 NP_032388.1 interleukin-1 receptor type 1 isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables interleukin-1 binding IPI
IPI: Inferred from physical interaction
23395675 MGI
enables interleukin-1 receptor activity IDA
IDA: Inferred from direct assay
10854325 MGI
enables interleukin-1 receptor activity IMP
IMP: Inferred from mutant phenotype
23395675 MGI
enables protease binding IPI
IPI: Inferred from physical interaction
12135759 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
1828071 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cytokine-mediated signaling pathway IDA
IDA: Inferred from direct assay
11880380 MGI
involved in interleukin-1-mediated signaling pathway IDA
IDA: Inferred from direct assay
10854325 MGI
acts upstream of or within positive regulation of interleukin-1-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
23395675 MGI
acts upstream of or within positive regulation of neutrophil extravasation IMP
IMP: Inferred from mutant phenotype
23395675 MGI
acts upstream of or within regulation of inflammatory response IMP
IMP: Inferred from mutant phenotype
22297845 MGI
Cellular Component GO Annotation Evidence References Source
located in cell surface IDA
IDA: Inferred from direct assay
19833765 MGI
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
23034280 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

interleukin-1 receptor type 1

  • CD121 antigen-like family member A

  • IL-1 receptor alpha chain

  • interleukin-1 receptor alpha

Recombinant Il1r1 Proteins

Cat. No. Product Name Accession Purity
HY-P70286 IL-1R1 Protein, Mouse (HEK293, His) P13504 (L20-K338) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Inhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-108841 Raleukin Antagonist 99.40% Unkown
HY-108822 Rilonacept Inhibitor ≥95.0% Unkown

Pre-clinical Phase

Bioactive Molecules (9)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P1110 AF12198 Inhibitor 99.92% Unkown
HY-P10474 RYTVELA 98.89% Unkown
HY-183344 IL-1β-IN-4 Inhibitor / Unkown
HY-E70731 IRAK4 aa104-460 Recombinant Human Active Protein Kinase / Unkown
HY-N19801 N-Palmitoyl-D-glucosamine / Unkown
HY-RS06720 IL1R1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174626 Human IL1R1 mRNA / Unkown
HY-RS20038 Il1r1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26541 Il1r1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P99140 Anti-Mouse IL-1R Antibody (JAMA-147) Inhibitor 95.00% Unkown
HY-P990321 AMG-108 Inhibitor ≥99.0% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Il1r1 NCBI NCBI:3554