Anti-Mouse TCR gamma/delta Antibody (UC7-13D5)
Based on 1 Customer Validation
Anti-Mouse TCR gamma/delta Antibody (UC7-13D5) is an anti-mouse TCR gamma/delta IgG monoclonal antibody. Anti-Mouse TCR gamma/delta Antibody (UC7-13D5) can enter the blood-brain barrier. Anti-Mouse TCR gamma/delta Antibody (UC7-13D5) effectively depletes γδ T cells and reduces macrophage and neutrophil infiltration. Anti-Mouse TCR gamma/delta Antibody (UC7-13D5) can reduce the immune response of transplants. Anti-Mouse TCR gamma/delta Antibody (UC7-13D5) can be used for researches on inflammation conditions, virus infection and cancer such as arthritis, JHM virus and breast cancer.
For research use only. We do not sell to patients.
- Purity : 98.26%
- Molecular Weight:150 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Isotype
Armenian Hamster IgG
Recommend Isotype Controls
Species Reactivity
Mouse
In Vitro
Anti-Mouse TCR gamma/delta Antibody (UC7-13D5) (200 μg, 2 days) significantly reduces the number of γδ T cells in spleen and lymph nodes of mice[2].
Anti-Mouse TCR gamma/delta Antibody (UC7-13D5) (5 μg/mL, 48 h) enhances IFN-γ production in γδ T cells[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:γδ T cells
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Concentration:5 μg/mL, co-incubation with PSK (100 μg/mL)
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Incubation Time:48 h
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Result:Significantly increased the level of IFN-γ to 12823 pg/mL.
In Vivo
Anti-Mouse TCR gamma/delta Antibody (UC7-13D5) (200 μg, i.p., on day 0, 5 and 10) significantly reduces the incidence rate of arthritis in male B10.RIII mice with an IL-23 induced arthritis[2].
Anti-Mouse TCR gamma/delta Antibody (UC7-13D5) (200 μg, i.p., twice weekly, for 4 weeks) can deplete γδ T cells in neu-transgenic mice bearing MMC tumors[3].
Anti-Mouse TCR gamma/delta Antibody (UC7-13D5) (500 µg, i.p., single dose, on day -3) significantly inhibits T cell infiltration in female BDF1 mice with a graft-versus-host disease (GVHD) model[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:1000 PFU JHM virus injected TCRβ-/- mice[1]
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Dosage:250 μg
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Administration:Intraperitoneal injection (i.p.), on day 0, 3, 6, 9 and 12
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Result:Significantly reduced the number of gamma delta T cells.
Reduced the degree of demyelination by 73 %.
Significantly improved clinical scores without limb paralysis.
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Animal Model:IL-23 induced male B10.RIII mice (12-14 weeks)[2]
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Dosage:200 μg
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Administration:Intraperitoneal injection (i.p.), on day 0, 5 and 10
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Result:Significantly reduced the incidence rate of arthritis to 46.15 % (80 % in the control group) and reduced the disease severity score.
Reduced the accumulation of neutrophils in the blood, spleen, bone marrow, and joints.
Significantly reduced serum IL-17A levels and increased IL-27 p28 levels.
Reduced synovial hyperplasia in joints.
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Animal Model:1×106 MMC cells injected neu-transgenic mice[3]
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Dosage:200 μg, combined with PSK (100 mg/kg)
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Administration:Intraperitoneal injection (i.p.), twice weekly for 4 weeks
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Result:Significantly weakened the anti-tumor effect of PSK and increased tumor volume.
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Animal Model:2×108 splenocytes of B6 mice injected female BDF1 mice (8-10 weeks)[4]
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Dosage:500 µg
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Administration:Intraperitoneal injection (i.p.), single dose, on day -3
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Result:Significantly inhibited the infiltration of donor derived T cells into intestinal epithelium to 32 %.
Significantly reduced the mitotic index (MI) and apoptosis index (AI) of crypt cells.
Significantly reduced intestinal lesions.
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
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Product Image
Application
in vivo TCR γ/δ neutralization; in vitro γ/δ T cell stimulation; in vitro γ/δ T cell purification;
Chemical Information
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Appearance Liquid
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Molecular Weight 150 kDa
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Color Colorless to light yellow
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SMILES
[Anti-Mouse TCR gamma/delta Antibody (UC7-13D5)]
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (266 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
[1]. Dandekar AA, et al. Important roles for gamma interferon and NKG2D in gammadelta T-cell-induced demyelination in T-cell receptor beta-deficient mice infected with a coronavirus. J Virol. 2005 Aug;79(15):9388-96. [Content Brief]
[2]. Bouchareychas L, et al. γδTCR regulates production of interleukin-27 by neutrophils and attenuates inflammatory arthritis. Sci Rep. 2018 May 15;8(1):7590. [Content Brief]
[3]. Inatsuka C, et al. Gamma delta T cells are activated by polysaccharide K (PSK) and contribute to the anti-tumor effect of PSK. Cancer Immunol Immunother. 2013 Aug;62(8):1335-45. [Content Brief]
[4]. Sakai T, et al. Host intestinal intraepithelial gamma delta T lymphocytes present during acute graft-versus-host disease in mice may contribute to the development of enteropathy. Eur J Immunol. 1995 Jan;25(1):87-91. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anti-Mouse TCR gamma/delta Antibody (UC7-13D5) Related Classifications
HY-P99146 Related Classifications
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