anti-TNBC agent-16
anti-TNBC agent-16 is a ferrochelatase inhibitor that accumulates intracellular PpIX and generates ROS under light irradiation. anti-TNBC agent-16 is used in research on triple-negative breast cancer.
For research use only. We do not sell to patients.
- Formula: C19H21FN2O5
- Molecular Weight:376.38
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
Description
Cellular Effect
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| MCF7 | IC50 |
96.62 μM
|
Phototoxicity against human breast adenocarcinoma MCF-7 cells assessed as reduction in cell viability after 4 hrs incubation followed by blue light irradiation at 405 nm and 18 hrs post-irradiation incubation by MTT assay.
Phototoxicity against human breast adenocarcinoma MCF-7 cells assessed as reduction in cell viability after 4 hrs incubation followed by blue light irradiation at 405 nm and 18 hrs post-irradiation incubation by MTT assay.
|
42586492 |
| MDA-MB-231 | IC50 |
49.65 μM
|
Phototoxicity against human triple-negative breast cancer MDA-MB-231 cells assessed as reduction in cell viability after 4 hrs incubation followed by blue light irradiation at 405 nm and 18 hrs post-irradiation incubation by MTT assay.
Phototoxicity against human triple-negative breast cancer MDA-MB-231 cells assessed as reduction in cell viability after 4 hrs incubation followed by blue light irradiation at 405 nm and 18 hrs post-irradiation incubation by MTT assay.
|
42586492 |
In Vitro
anti-TNBC agent-16 (Compound 13d) (20-100 μM; 4 h) exhibits potent, light-dependent phototoxicity against MCF-7 and MDA-MB-231 cells with IC50 values of 96.62 μM and 49.65 μM, respectively, while showing minimal dark toxicity[1].
anti-TNBC agent-16 (100 μM) significantly enhances intracellular PpIX accumulation in MDA-MB-231 cells, resulting in a 3.83-fold higher fluorescence level at 100 μM compared to free 5-ALA[1].
anti-TNBC agent-16 (4 h) demonstrates a potent light-triggered ROS-generating capacity in MDA-MB-231 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:MCF-7 and MDA-MB-231
-
Concentration:20; 40; 60; 80; 100 μM
-
Incubation Time:4 h (pre-irradiation); 18 h (post-irradiation)
-
Result:Exhibited an IC50 of 96.62 μM in MCF-7 cells.
Exhibited an IC50 of 49.65 μM in MDA-MB-231 cells.
Displayed negligible dark toxicity in both cell lines across the tested concentration gradient.
Chemical Information
-
Molecular Weight 376.38
-
Formula C19H21FN2O5
-
SMILES
O=C(O[C@H](C1=CC=C(F)C=C1)CN(C(C)=C2O)C=CC2=O)CCC(CN)=O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
anti-TNBC agent-16 Related Classifications
HY-189420 Related Classifications
Powered by Bioz