Antibacterial agent 140 chloride
Antibacterial agent 140 chloride is a promising antibacterial agent. Antibacterial agent 140 chloride is also the first Ru-based AIEgen?photosensitizer?for simultaneous dual applications of?Gram-positive bacteria (G+)?detection. Antibacterial agent 140 chloride uniquely selective discriminates and efficient exterminates Gram-positive bacteria (G+)?from other bacteria due to its interaction with?lipoteichoic acids?(LTA). Antibacterial agent 140 chloride ?also possessed robust?antibacterial activity?for?G+ under?light irradiation.
For research use only. We do not sell to patients.
- Formula: C61H44Cl2N8Ru2-
- Molecular Weight:1162.10
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Antibacterial agent 140 chloride（0.1-5 μg/mL；1 h) exhibits a dose-dependent viability from 78% to 0% in the dark, demonstrating the dark toxicity of Ru2 toward S. aureus[1]. Antibacterial agent 140 chloride（0.1-5 μg/mL；1 h) displays an obvious dose-dependent and time-dependent killing efficiencies upon 120s light irradiation, Ru2 almost completely inhibited the growth of S. aureus at a very low concentration upon light irradiation[1]. Antibacterial agent 140 chloride（0-32 μM；1 h）exhibits more than 80% of HeLa cells remained alive after incubation with < 32 μM in the dark. It leads to >73% of HeLa cells alive at concentrations of ≤32 μM under the light irradiation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female Kunming mice (5-6 weeks old) mice model with skin infected by S. aureus.[1]
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Dosage:50 μL (20 μg/mL)
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Administration:50 μL (20 μg/mL); skin application; 1-10 days
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Result:99.50% of the infected wound areas were healed after 10 days under Ru2/light treatment. Exhibited photodynamic antibacterial therapeutic efficacy.
Chemical Information
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Molecular Weight 1162.10
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Formula C61H44Cl2N8Ru2-
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SMILES
CC(C)(C1=CC=C(C=C1)N2C(C3=CC4=C(C5=C3C=CC=C5)C=CC=C4)=NC6=C2C7=C8C9=C6C=CC=[N]9[Ru]%10%11([N]8=CC=C7)([N]%12=C%13C(C=CC%14=CC=C[N]%11=C%14%13)=CC=C%12)([Ru+])[N]%15=C%16C(C=CC%17=CC=C[N]%10=C%17%16)=CC=C%15)C.[Cl-].[Cl-]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (285 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antibacterial agent 140 chloride Related Classifications
HY-149801A Related Classifications
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