Antibacterial agent 140 chloride 

Antibacterial agent 140 chloride is a promising antibacterial agent. Antibacterial agent 140 chloride is also the first Ru-based AIEgen photosensitizer for simultaneous dual applications of Gram-positive bacteria (G+) detection and treatment. Antibacterial agent 140 chloride uniquely selective discriminates and efficient exterminates Gram-positive bacteria (G+) from other bacteria due to its interaction with lipoteichoic acids (LTA). Antibacterial agent 140 chloride  also possessed robust antibacterial activity for G+ under light irradiation^[1].

Antibacterial agent 140 chloride（0.1-5 μg/mL；1 h) exhibits a dose-dependent viability from 78% to 0% in the dark, demonstrating the dark toxicity of Ru2 toward S. aureus^[1].
Antibacterial agent 140 chloride（0.1-5 μg/mL；1 h) displays an obvious dose-dependent and time-dependent killing efficiencies upon 120s light irradiation, Ru2 almost completely inhibited the growth of S. aureus at a very low concentration upon light irradiation^[1].
Antibacterial agent 140 chloride（0-32 μM；1 h）exhibits more than 80% of HeLa cells remained alive after incubation with < 32 μM in the dark. It leads to >73% of HeLa cells alive at concentrations of ≤32 μM under the light irradiation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Antibacterial agent 140 chloride（20 μg/mL/50 μL; 1-10 days) displays a remarkable reduction in wound size under light irradiation, it results in almost complete wound healing after 7 day in female Kunming mice after S. aureus. infection^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1162.10

C₆₁H₄₄Cl₂N₈Ru₂^-

CC(C)(C1=CC=C(C=C1)N2C(C3=CC4=C(C5=C3C=CC=C5)C=CC=C4)=NC6=C2C7=C8C9=C6C=CC=[N]9[Ru]%10%11([N]8=CC=C7)([N]%12=C%13C(C=CC%14=CC=C[N]%11=C%14%13)=CC=C%12)([Ru+])[N]%15=C%16C(C=CC%17=CC=C[N]%10=C%17%16)=CC=C%15)C.[Cl-].[Cl-]

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Mengling Liu, et al. Specific discrimination and efficient elimination of gram-positive bacteria by an aggregation-induced emission-active ruthenium (II) photosensitizer. Eur J Med Chem. 2023 May 5;251:115249.  [Content Brief]