ALDH1B1 Antibody
(Synonyms: ALDH5, ALDHX, ALDH1B1, Aldehyde dehydrogenase 5, Aldehyde dehydrogenase family 1 member B1)ALDH1B1 Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to ALDH1B1.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Conjugation:
Non-conjugated
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Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|---|
| Dilution Ratio | 1:1000-2000 | 1:100-200 |
Product Details
ALDH1B1 Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to ALDH1B1.
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Host Rabbit
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Clonality Polyclonal
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 57 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 57 kDa
Synthetic peptide corresponding to the center region of human ALDH1B1.
Endogenous
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
ALDH1B1 is a Broad specificity, mitochondrial aldehyde dehydrogenase that could play a role in the detoxification of alcohol-derived acetaldehyde and other aldehydes. Shows an absolute preference for NAD(+) as no activity is detected with NADP(+). Has a high affinity and catalytic efficiency toward aliphatic medium-chain saturated aldehydes relative to short-chain and aromatic aldehydes in vitro. Also capable of metabolizing products of lipid peroxidation, namely 4-hydroxynon-2-enal(4-HNE) and malonaldehyde (MDA) but with lower catalytic efficiency. In vitro, it can also display a nitroglycerin reductase activity. Has also an esterase activity in vitro, but this may be not physiologically relevant in vivo[1][2][3].
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Subcellular Localization
Mitochondrion matrix
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Expression
Tissue_Specificity: Liver, testis and to a lesser extent in brain. -
Isoforms & Post-Translational Modification
ALDH1B1 has an amino acid length of 517, molecular weight is 57249 Da.
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Subunit
Homotetramer
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SwissProt ID
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Synonyms
ALDH5, ALDHX, ALDH1B1, Aldehyde dehydrogenase 5, Aldehyde dehydrogenase family 1 member B1
Documentation
[1]. Stagos D, et al. Aldehyde dehydrogenase 1B1: molecular cloning and characterization of a novel mitochondrial acetaldehyde-metabolizing enzyme. Drug Metab Dispos. 2010 Oct;38(10):1679-87. [Content Brief]
[2]. Jackson BC, et al. Human ALDH1B1 polymorphisms may affect the metabolism of acetaldehyde and all-trans retinaldehyde--in vitro studies and computational modeling. Pharm Res. 2015 May;32(5):1648-62. [Content Brief]
[3]. Feng Z, et al. Targeting colorectal cancer with small-molecule inhibitors of ALDH1B1. Nat Chem Biol. 2022 Oct;18(10):1065-1075. [Content Brief]
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