alpha COP I Antibody (YA2105)
(Synonyms: Alpha COP; Alpha COPI; AlphaCOP; COP A; copA; HEP COP; Proxenin; Xenin)alpha COP I Antibody (YA2105) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to alpha COP I.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|---|
| Dilution Ratio | 1:500-1:1000 | 1:50-1:100 |
Product Details
alpha COP I Antibody (YA2105) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to alpha COP I.
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Host Rabbit
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Clonality Recombinant, Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 138 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 138 kDa
Entrez Gene: 1314 Human ; 12847 Mouse ; 304978 Rat
SwissProt: P53621 Human ; Q8CIE6 Mouse ;
OMIM: 616414 Human
A synthesized peptide derived from human COPA aa1-29.
Endogenous
Affinity Purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
alpha COP I is a The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors; Xenin stimulates exocrine pancreatic secretion. It inhibits pentagastrin-stimulated secretion of acid, to induce exocrine pancreatic secretion and to affect small and large intestinal motility. In the gut, xenin interacts with the neurotensin receptor
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Subcellular Localization
Cytoplasm; Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side; Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side; Secreted
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Expression
Tissue_specificity:Uniformly expressed in a wide range of human tissues. Xenin is found in gastric, duodenal and jejunal mucosa. Circulates in the blood. Seems to be confined to specific endocrine cells -
Isoforms & Post-Translational Modification
P53621 has 2 isomers: P53621-1: 138346 Da (predicted); P53621-2: 139324 Da (predicted).
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Subunit
Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits (By similarity). Interacts with SCYL1 (By similarity). Interacts with JAGN1 (PubMed:25129144). Interacts with TMEM41B (PubMed:30352685). Interacts with SVEP1 (By similarity). Probably interacts with PEX11A
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SwissProt ID
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Synonyms
Alpha COP; Alpha COPI; AlphaCOP; COP A; copA; HEP COP; Proxenin; Xenin
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Research Field
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Documentation
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