COPA - COPI coat complex subunit alpha Gene

Also Known as AILJK; HEP-COP; alpha-COP

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 1314

About COPA

Cytogenetic location: 1q23.2 Genomic coordinates (GRCh38): 1:160,288,594-160,343,250 (from NCBI)

This gene has 35 transcripts (splice variants), 217 orthologues, 1 paralogue and is associated with 2 phenotypes. Ubiquitous expression in thyroid (RPKM 39.8), colon (RPKM 29.3) and 25 other tissues.

Summary

In eukaryotic cells, protein transport between the endoplasmic reticulum and Golgi compartments is mediated in part by non-clathrin-coated vesicular coat proteins (COPs). Seven coat proteins have been identified, and they represent subunits of a complex known as coatomer. The subunits are designated alpha-COP, beta-COP, beta-prime-COP, gamma-COP, delta-COP, epsilon-COP, and zeta-COP. The alpha-COP, encoded by COPA, shares high sequence similarity with RET1P, the alpha subunit of the coatomer complex in yeast. Also, the N-terminal 25 Amino acids of alpha-COP encode the bioactive peptide, xenin, which stimulates exocrine pancreatic secretion and may act as a gastrointestinal hormone. Alternative splicing results in multiple splice forms encoding distinct isoforms. [provided by RefSeq, Jul 2008]

COPA Products (4)

mRNA Protein Name
NM_001098398.2 NP_001091868.1 coatomer subunit alpha isoform 1
NM_004371.4 NP_004362.2 coatomer subunit alpha isoform 2
NM_001098398.2 NP_001091868.1 coatomer subunit alpha isoform 1
NM_004371.4 NP_004362.2 coatomer subunit alpha isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
16169070 GOA
Biological Process GO Annotation Evidence Verweise Source
acts upstream of or within pancreatic juice secretion IDA
IDA: Inferred from direct assay
1429581 GOA
Cellular Component GO Annotation Evidence Verweise Source
part of COPI vesicle coat IDA
IDA: Inferred from direct assay
14729954 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
9115636 GOA
located in extracellular space IDA
IDA: Inferred from direct assay
1429581 GOA
located in growth cone IDA
IDA: Inferred from direct assay
21300694 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

COPA Protein Structure

WD40

WD40: WD domain, G-beta repeat (3 - 37)

WD40

WD40: WD domain, G-beta repeat (44 - 79)

WD40

WD40: WD domain, G-beta repeat (84 - 121)

WD40

WD40: WD domain, G-beta repeat (126 - 163)

WD40

WD40: WD domain, G-beta repeat (197 - 232)

WD40

WD40: WD domain, G-beta repeat (244 - 277)

Coatomer_WDAD

Coatomer_WDAD: Coatomer WD associated region (342 - 767)

COPI_C

COPI_C: Coatomer (COPI) alpha subunit C-terminus (815 - 1224)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1224 a.a.
Protein Preferred Names Protein Names

coatomer subunit alpha

  • alpha coat protein

COPA Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
COPA P53621 COPE Homo sapiens O14579
Anti Tag CoIP
35271311
Cross: Cross-species interaction Intra: Intraspecies interaction

COPA Antibodies

Art. -Nr. Produktname Anwendung Reactivity
HY-P82360 alpha COP I Antibody (YA2105) WB, IHC-P Human, Mouse, Rat

Related Diseases

Diseases Alias
Autoimmune Interstitial Lung, Joint, And Kidney Disease

  • Autoimmune Interstitial Lung Disease-Arthritis Syndrome

  • AILJK

  • Copa Syndrome
Parainfluenza Virus Type 3

  • Human Parainfluenza Virus Type 3

  • Piv3
Lung Disease

  • Lung Diseases

  • Disorder Of Lung

  • Abnormality Of The Lung
Interstitial Lung Disease

  • Ild

  • Lung Diseases, Interstitial

  • Lung Diseases Interstitial

  • Interstitial Lung Diseases
Lipid Pneumonia

  • Exogenous Lipoid Pneumonia

  • Lipoid Pneumonitis

  • Pneumonia, Lipid

  • Pneumonia Lipid

  • Lipoid Pneumonia
Familial Cold Autoinflammatory Syndrome 3

  • Plaid

  • Familial Atypical Cold Urticaria

  • Facu

  • FCAS3

  • Antibody Deficiency And Immune Dysregulation, Plcg2-Associated

  • Plcg2-Associated Antibody Deficiency And Immune Dysregulation

  • Familial Cold Urticaria With Common Variable Immunodeficiency

  • Plcg2 Associated Antibody Deficiency And Immune Dysregulation

  • Antibody Deficiency And Immune Dysregulation Placg2-Associated

  • Autoinflammatory Syndrome, Cold, Familial, Type 3
Ventilation Pneumonitis

  • Air-Conditioner And Humidifier Lung

  • Humidifier Lung

  • Air Conditioner Lung

  • Air Humidifier Pneumonitis

  • Sauna Takers Lung

  • Air Conditioner Pneumonitis

  • Humidifier Pneumonitis

  • Air Humidifier Lung
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-P10914 D-CopA3 / Unkown
HY-RS03021 COPA Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19588 Copa Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26085 Copa Rat Pre-designed siRNA Set A Pre-designed Set / Unkown