COPE - COPI coat complex subunit epsilon Gene

Also Known as epsilon-COP

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 11316

About COPE

Cytogenetic location: 19p13.11 Genomic coordinates (GRCh38): 19:18,899,514-18,919,387 (from NCBI)

This gene has 11 transcripts (splice variants) and 207 orthologues. Ubiquitous expression in testis (RPKM 53.6), bone marrow (RPKM 48.5) and 25 other tissues.

Summary

The product of this gene is an epsilon subunit of coatomer protein complex. Coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles. It is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. Coatomer complex consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

COPE Products (8)

mRNA	Protein	Name
NM_001330469.2	NP_001317398.1	coatomer subunit epsilon isoform d
NM_007263.4	NP_009194.2	coatomer subunit epsilon isoform a
NM_199442.2	NP_955474.1	coatomer subunit epsilon isoform b
NM_199444.2	NP_955476.1	coatomer subunit epsilon isoform c
NM_001330469.2	NP_001317398.1	coatomer subunit epsilon isoform d
NM_007263.4	NP_009194.2	coatomer subunit epsilon isoform a
NM_199442.2	NP_955474.1	coatomer subunit epsilon isoform b
NM_199444.2	NP_955476.1	coatomer subunit epsilon isoform c

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16169070	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

COPE Protein Structure

Coatomer_E

0
100
200
308 a.a.

Protein Preferred Names	Protein Names
coatomer subunit epsilon	coatomer epsilon subunit

COPE Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	COPE	O14579	EFHC2	Homo sapiens	Q5JST6	Validated Y2H	32296183
Intra	COPE	O14579	EFHC2	Homo sapiens	Q5JST6	Y2H Array	32296183
Intra	COPE	O14579	EFHC2	Homo sapiens	Q5JST6	Y2H Prey Pooling	25416956
Intra	COPE	O14579	EFHC2	Homo sapiens	Q5JST6	Y2H Prey Pooling	32296183
Intra	COPE	O14579	COPA	Homo sapiens	P53621	Anti Tag CoIP	33961781
Intra	COPE	O14579	COPA	Homo sapiens	P53621	Y2H Pooling	16169070
Intra	COPE	O14579	COPA	Homo sapiens	P53621	Anti Tag CoIP	35271311
Intra	COPE	O14579	CDC42EP3	Homo sapiens	Q9UKI2	Y2H Prey Pooling	32296183
Intra	COPE	O14579	CDC42EP3	Homo sapiens	Q9UKI2	Validated Y2H	32296183
Intra	COPE	O14579	CDC42EP3	Homo sapiens	Q9UKI2	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Neuroschistosomiasis
Cardiomyopathy, Familial Restrictive, 2	RCM2 Restrictive Cardiomyopathy 2 Familial Restrictive Cardiomyopathy 2 Cardiomyopathy, Restrictive, Familial, Type 2
Developmental And Epileptic Encephalopathy 48	DEE48 Epileptic Encephalopathy, Early Infantile, 48 Eiee48 Developmental And Epileptic Encephalopathy, 48 Early Infantile Epileptic Encephalopathy 48
Spastic Paraplegia 39, Autosomal Recessive	SPG39 Ntemnd Hereditary Spastic Paraplegia 39 Nte-Related Motor Neuron Disorder Autosomal Recessive Spastic Paraplegia Type 39 Spastic Paraplegia Due To Neuropathy Target Esterase Mutation Spastic Paraplegia Due To Nte Mutation Spastic Paraplegia 39 Autosomal Recessive Spastic Paraplegia 39 Nte Related Motor Neuron Disorder Paraplegia, Spastic, Type 39
Geroderma Osteodysplasticum	Gerodermia Osteodysplastica Geroderma Osteodysplastica GO Walt Disney Dwarfism Type Of Gerodermia Osteodysplastica

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-Y0549	Diphenylacetic acid		99.96%	Unkown
HY-RS03024	COPE Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-N9928	Echinenone	Inhibitor	/	Unkown
HY-RS19886	Cope Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26386	Cope Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	COPE	RGD	RGD:1306785
Canis familiaris	COPE	VGNC	VGNC:39506
Felis catus	COPE	VGNC	VGNC:61083
Mus musculus	COPE	MGD	MGI:1891702
Macaca mulatta	COPE	VGNC	VGNC:71314
Bos taurus	COPE	VGNC	VGNC:27595
Others	COPE	NCBI