CDC42EP3 - CDC42 effector protein 3 Gene

Also Known as UB1; CEP3; BORG2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10602

About CDC42EP3

Cytogenetic location: 2p22.2 Genomic coordinates (GRCh38): 2:37,641,944-37,672,949 (from NCBI)

This gene has 6 transcripts (splice variants), 207 orthologues and 5 paralogues. Broad expression in prostate (RPKM 28.7), endometrium (RPKM 27.8) and 23 other tissues.

Summary

This gene encodes a member of a small family of guanosine triphosphate (GTP) metabolizing proteins that contain a CRIB (Cdc42, Rac interactive binding) domain. Members of this family of proteins act as effectors of CDC42 function. The encoded protein is involved in actin Cytoskeleton re-organization during cell shape changes, including pseudopodia formation. A pseudogene of this gene is found on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]

CDC42EP3 Products (6)

mRNA	Protein	Name
NM_001270436.2	NP_001257365.1	cdc42 effector protein 3
NM_001270437.2	NP_001257366.1	cdc42 effector protein 3
NM_001270438.2	NP_001257367.1	cdc42 effector protein 3
NM_001371569.1	NP_001358498.1	cdc42 effector protein 3
NM_001371570.1	NP_001358499.1	cdc42 effector protein 3
NM_006449.5	NP_006440.2	cdc42 effector protein 3

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	24947832	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CDC42EP3 Protein Structure

PBD

BORG_CEP

0
100
200
254 a.a.

Protein Preferred Names	Protein Names
cdc42 effector protein 3	CDC42 effector protein (Rho GTPase binding) 3

CDC42EP3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CDC42EP3	Q9UKI2	LRRK2	Homo sapiens	Q5S007	Protein Array	24947832
Intra	CDC42EP3	Q9UKI2	LRRK2	Homo sapiens	Q5S007	Protein Array	29513927

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Vertebrobasilar Insufficiency	Vertebro-Basilar Insufficiency Vertebrobasilar Arterial Insufficiency Vertebrobasilar Artery Syndrome
Retinitis Pigmentosa 11	RP11 Retinitis Pigmentosa-11 Retinitis Pigmentosa, Type 11
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02304	CDC42EP3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	CDC42EP3	VGNC	VGNC:39002
Rattus norvegicus	CDC42EP3	RGD	RGD:1305858
Macaca mulatta	CDC42EP3	VGNC	VGNC:70777
Mus musculus	CDC42EP3	MGD	MGI:2384718
Bos taurus	CDC42EP3	VGNC	VGNC:27074
Felis catus	CDC42EP3	VGNC	VGNC:60661
Others	CDC42EP3	NCBI