ATP2C1 Antibody (YA4144)(PBS only)
(Synonyms: HHD; BCPM; PMR1; SPCA1)ATP2C1 Antibody (YA4144) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to ATP2C1.
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Host:
Mouse
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Isotype:
IgG1
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Application:
WB, IHC-P, ELISA
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Reactivity :
Human, Monkey
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Formulation:
Supplied in PBS, pH 7.4.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|---|
| Dilution Ratio | 1:500-1:2000 | 1:200-1:1000 | 1:10000 |
Product Details
ATP2C1 Antibody (YA4144) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to ATP2C1.
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Host Mouse
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Species ReactivityHuman, Monkey
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Observed Molecular WeightObserved band size: 101 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 101 kDa
Purified recombinant fragment of ATP2C1 aa 119-269.
affinity purified.
Non-conjugated
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS, pH 7.4.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
ATP2C1 is an ATP-driven pump that supplies the Golgi apparatus with Ca(2+) and Mn(2+) ions, both essential cofactors for processing and trafficking of newly synthesized proteins in the secretory pathway. Within a catalytic cycle, acquires Ca(2+) or Mn(2+) ions on the cytoplasmic side of the membrane and delivers them to the lumenal side. The transfer of ions across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation that shifts the pump conformation from inward-facing to outward-facing state. Plays a primary role in the maintenance of Ca(2+) homeostasis in the trans-Golgi compartment with a functional impact on Golgi and post-Golgi protein sorting as well as a structural impact on cisternae morphology. Responsible for loading the Golgi stores with Ca(2+) ions in keratinocytes, contributing to keratinocyte differentiation and epidermis integrity. Participates in Ca(2+) and Mn(2+) ions uptake into the Golgi store of hippocampal neurons and regulates protein trafficking required for neural polarity. May also play a role in the maintenance of Ca(2+) and Mn(2+) homeostasis and signaling in the cytosol while preventing cytotoxicity[1][2][3][4][5][6][7][8].
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Subcellular Localization
Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein; Golgi apparatus, Golgi stack membrane; Multi-pass membrane protein
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Expression
Tissue_specificity:It has been found in most tissues except the colon, thymus, spleen, and leukocytes (PubMed:15831496) . It is expressed in keratinocytes (protein level) (PubMed:14632183, PubMed:15831496) . -
Isoforms & Post-Translational Modification
P98194 has 9 isomers: P98194-1: 100577 Da (predicted); P98194-2: 96960 Da (predicted); P98194-3: 101163 Da (predicted); P98194-4: 98733 Da (predicted); P98194-5: 103007 Da (predicted); P98194-6: 105057 Da (predicted); P98194-7: 107143 Da (predicted); P98194-8: 103524 Da (predicted); P98194-9: 104032 Da (predicted).
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Subunit
Monomer. Homodimer
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SwissProt ID
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Synonyms
HHD; BCPM; PMR1; SPCA1
Documentation
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