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Cat. No.: HY-P87574

AZI2 Antibody (YA7258)

AZI2 Antibody (YA7258) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to AZI2.

For research use only. We do not sell to patients.

Formulation:
Supplied in 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Applications

Application	ICC/IF ICC/IF: Immunocytochemistry/ Immunofluorescence
Dilution Ratio	1:50-200

Description

AZI2 Antibody (YA7258) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to AZI2.

Host Rabbit
Clonality Recombinant,Monoclonal
Observed Molecular Weight

Observed band size: 45 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Calculated Molecular Weight Predicted band size: 45 kDa

Immunogen

A synthesized peptide derived from human AZI2

Sensitivity

Endogenous

Purification

affinity purified by Protein A

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG

Appearance

Liquid
Formulation

Supplied in 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.

Function

AZI2 is an Adapter protein which binds TBK1 and IKBKE playing a role in antiviral innate immunity. Activates serine/threonine-protein kinase TBK1 and facilitates its oligomerization. Enhances the phosphorylation of NF-kappa-B p65 subunit RELA by TBK1. Promotes TBK1-induced as well as TNF-alpha or PMA-induced activation of NF-kappa-B. Participates in IFNB promoter activation via TICAM1^[1]^[2]^[3].
Subcellular Localization

Cytoplasm
Expression

Tissue_Specificity: Widely expressed (PubMed:14560022). Abundant expression seen in the pancreas and testis (PubMed:14560022)
Isoforms & Post-Translational Modification

Q9H6S1 has four isomers: Q9H6S1-1: 44935 Da (predicted); Q9H6S1-3: 26510 Da (predicted); Q9H6S1-4: 28188 Da (predicted); Q9H6S1-5: 26921 Da (predicted).
Ubiquitinated via 'Lys-48'-linked polyubiquitination by TRIM38, leading to its degradation
Subunit

Homodimer (By similarity)
SwissProt ID

Q9H6S1