CCL11 Antibody
(Synonyms: Scya11, Ccl11, Eotaxin, C-C motif chemokine 11, Eosinophil chemotactic protein, Small-inducible cytokine A11)CCL11 Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to CCL11.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, ICC/IF
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|---|
| Dilution Ratio | 1:1000-2000 | 1:50-200 |
Product Details
CCL11 Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to CCL11.
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Host Rabbit
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Clonality Polyclonal
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 18 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 10 kDa
Synthetic peptide corresponding to the center region of human CCL11.
Endogenous
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
CCL11 is a Chemokine that plays a central role in both allergic and non-allergic inflammatory reactions by inducing the migration of different leukocyte types including eosinophils, basophils, macrophages and dendritic cells. Exerts its effects primarily by binding to the CCR3 receptor. Induces also chemotaxis of endothelial cells and promotes angiogenesis by activating the PI3K/Akt pathway[1][2][3][4].
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Subcellular Localization
Secreted
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Expression
Induction: Induced by TNF, IL1A/interleukin-1 alpha and IFNG/IFN-gamma. -
Isoforms & Post-Translational Modification
CCL11 has an amino acid length of 97, molecular weight is 10732 Da.O 连接聚糖由 Gal-GalNAc 二糖组成，可被最多 2 个唾液酸残基修饰CCL11 的氨基酸个数为 97 个，分子量为 10732 Da。O-linked glycan consists of a Gal-GalNAc disaccharide which is modified with up to 2 sialic acid residues
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SwissProt ID
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Synonyms
Scya11, Ccl11, Eotaxin, C-C motif chemokine 11, Eosinophil chemotactic protein, Small-inducible cytokine A11
Documentation
[1]. Garcia-Zepeda EA, et al. Human eotaxin is a specific chemoattractant for eosinophil cells and provides a new mechanism to explain tissue eosinophilia. Nat Med. 1996 Apr;2(4):449-56. [Content Brief]
[2]. Wakabayashi K, et al. Eotaxin-1/CCL11 is involved in cell migration in rheumatoid arthritis. Sci Rep. 2021 Apr 12;11(1):7937. [Content Brief]
[3]. Kitaura M, et al. Molecular cloning of human eotaxin, an eosinophil-selective CC chemokine, and identification of a specific eosinophil eotaxin receptor, CC chemokine receptor 3. J Biol Chem. 1996 Mar 29;271(13):7725-30. [Content Brief]
[4]. Park JY, et al. CCL11 promotes angiogenic activity by activating the PI3K/Akt pathway in HUVECs. J Recept Signal Transduct Res. 2017 Aug;37(4):416-421. [Content Brief]
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