CD226/DNAM1 Antibody (YA2412)
(Synonyms: CD226; DNAM1; CD226 antigen; DNAX accessory molecule 1; DNAM-1; CD antigen CD226)CD226/DNAM1 Antibody (YA2412) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CD226/DNAM1.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB
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Reactivity :
Human
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Formulation:
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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|---|---|
| Dilution Ratio | 1:500-1:1000 |
Product Details
CD226/DNAM1 Antibody (YA2412) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CD226/DNAM1.
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Host Rabbit
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Clonality Recombinant, Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 60-80 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 39 kDa
A synthetic peptide of human CD226
Endogenous
Affinity Purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
CD226/DNAM1 cell surface receptor that plays an important role in the immune system, particularly in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-cells and NK cells. Functions as a costimulatory receptor upon recognition of target cells, such as virus-infected or tumor cells. Upon binding to its ligands PVR/CD155 or NECTIN2/CD112 on target cells, promotes the cytotoxic activity of NK cells and CTLs, enhancing their ability to kill these cells. Mechanistically, phosphorylation by Src kinases such as LYN of FYN, enables binding to adapter GRB2, leading to activation of VAV1, PI3K and PLCG1. Promotes also activation of kinases ERK and AKT, as well as calcium fluxes[1][2][3][4][5].
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Subcellular Localization
Cell membrane; Single-pass type I membrane protein
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Expression
Tissue_specificity:Expressed by peripheral blood T-lymphocytes. -
Subunit
Interacts with PVR and NECTIN2 (PubMed:15039383, PubMed:15607800, PubMed:31253644, PubMed:30591568). Competes with PVRIG for NECTIN2-binding (PubMed:26755705).
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SwissProt ID
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Synonyms
CD226; DNAM1; CD226 antigen; DNAX accessory molecule 1; DNAM-1; CD antigen CD226
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Research Field
Immunology
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