CD226 - CD226 molecule Gene

Also Known as PTA1; DNAM1; DNAM-1; TLiSA1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10666

About CD226

Cytogenetic location: 18q22.2 Genomic coordinates (GRCh38): 18:69,853,274-69,961,773 (from NCBI)

This gene has 8 transcripts (splice variants), 185 orthologues and 14 paralogues. Broad expression in spleen (RPKM 2.4), lymph node (RPKM 1.3) and 15 other tissues.

Summary

This gene encodes a glycoprotein expressed on the surface of NK cells, platelets, monocytes and a subset of T cells. It is a member of the Ig-superfamily containing 2 Ig-like domains of the V-set. The protein mediates cellular adhesion of platelets and megakaryocytic cells to vascular endothelial cells. The protein also plays a role in megakaryocytic cell maturation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

CD226 Products (3)

mRNA	Protein	Name
NM_001303618.2	NP_001290547.1	CD226 antigen isoform a precursor
NM_001303619.2	NP_001290548.1	CD226 antigen isoform b
NM_006566.4	NP_006557.2	CD226 antigen isoform a precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables cell adhesion molecule binding	IPI IPI: Inferred from physical interaction	12913096	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	25465800	GOA
enables integrin binding	IPI IPI: Inferred from physical interaction	16831868	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21982860	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	16831868	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of Fc receptor mediated stimulatory signaling pathway	IDA IDA: Inferred from direct assay	16831868	GOA
involved in positive regulation of T cell receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	26755705	GOA
involved in positive regulation of immunoglobulin mediated immune response	IDA IDA: Inferred from direct assay	16831868	GOA
involved in positive regulation of mast cell activation	IDA IDA: Inferred from direct assay	16831868	GOA
involved in positive regulation of natural killer cell mediated cytotoxicity	IMP IMP: Inferred from mutant phenotype	16304049	GOA
involved in positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	IMP IMP: Inferred from mutant phenotype	12913096	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cell surface	IDA IDA: Inferred from direct assay	16831868	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CD226 Protein Structure

V-set

Ig_2

0
100
200
300
336 a.a.

Protein Preferred Names	Protein Names
CD226 antigen	DNAX accessory molecule-1

CD226 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CD226	Q15762	PVR	Homo sapiens	P15151	SPR	30591568
Intra	CD226	Q15762	PVR	Homo sapiens	P15151	Protein Array	21982860
Intra	CD226	Q15762	ATP12A	Homo sapiens	P54707	Anti Tag CoIP	33961781
Intra	CD226	Q15762	EIF2B3	Homo sapiens	Q9NR50	Anti Tag CoIP	33961781
Intra	CD226	Q15762	BSCL2	Homo sapiens	Q96G97	Anti Tag CoIP	33961781
Intra	CD226	Q15762	ARL10	Homo sapiens	Q8N8L6	Anti Tag CoIP	33961781
Intra	CD226	Q15762	TIGIT	Homo sapiens	Q495A1	Anti Tag CoIP	25465800
Intra	CD226	Q15762	ATR	Homo sapiens	Q13535	Anti Tag CoIP	33961781
Intra	CD226	Q15762	EIF2B2	Homo sapiens	P49770	Anti Tag CoIP	33961781
Intra	CD226	Q15762	CD226	Homo sapiens	Q15762	FRET	25465800
Intra	CD226	Q15762	EIF2B4	Homo sapiens	Q9UI10	Anti Tag CoIP	33961781
Intra	CD226	Q15762	ATP2B3	Homo sapiens	Q16720	Anti Tag CoIP	33961781
Intra	CD226	Q15762	NECTIN2	Homo sapiens	Q92692	Protein Array	21982860
Intra	CD226	Q15762	EIF2B5	Homo sapiens	Q13144	Anti Tag CoIP	33961781
Intra	CD226	Q15762	CD226	Homo sapiens	Q15762	X-Ray Diffraction	30591568
Intra	CD226	Q15762	DSTYK	Homo sapiens	Q6XUX3	Anti Tag CoIP	33961781
Intra	CD226	Q15762	C4A	Homo sapiens	P0C0L4	Anti Tag CoIP	33961781
Intra	CD226	Q15762	TIGIT	Homo sapiens	Q495A1	FRET	25465800
Intra	CD226	Q15762	CDK5RAP3	Homo sapiens	Q96JB5	Anti Tag CoIP	33961781
Intra	CD226	Q15762	ATP13A1	Homo sapiens	Q9HD20	Anti Tag CoIP	33961781
Intra	CD226	Q15762	EIF2B1	Homo sapiens	Q14232	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CD226 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70829	DNAM-1 Protein, Human (HEK293, Fc)	Q15762 (E19-N247)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P72668	DNAM-1 Protein, Human (HEK293, His)	Q15762 (E19-N247)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P78114	DNAM-1 Protein, Human (Biotinylated, HEK293, His-Avi)	Q15762 (E19-N247)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P78429	DNAM-1 Protein, Human (HEK293, His-Avi)	Q15762 (E19-N247)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P78886	DNAM-1 Protein, Human (Biotinylated, HEK293, Fc-Avi)	Q15762 (E19-N247)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P700441	DNAM-1 Protein, Human (HEK293, hFc, Myc)	Q15762 (E19-N247)	≥ 95%, as determined by reducing SDS-PAGE.

CD226 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81691	CD226/DNAM1 Antibody (YA1436)	FC, ELISA	Human
HY-P82667	CD226/DNAM1 Antibody (YA2412)	WB	Human
HY-P82667A	CD226/DNAM1 Antibody (YA2412)(PBS only)	WB	Human
HY-P84599	CD226/DNAM1 Antibody (YA4296)	IHC-P, FC, ELISA	Human
HY-P84599A	CD226/DNAM1 Antibody (YA4296)(PBS only)	IHC-P, FC, ELISA	Human

Related Diseases

Diseases	Alias
Mature Teratoma Of The Ovary
Ovarian Cystic Teratoma
Nk Cell Deficiency
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]
Leukemia, Acute Myeloid	Acute Myeloid Leukemia Leukemia, Acute Myelogenous Acute Myelogenous Leukemia AML Leukemia, Acute Myeloid, Susceptibility To Acute Myeloblastic Leukemia Leukemia, Acute Myeloid, Reduced Survival In, Somatic Acute Myeloid Leukaemia Leukemia, Myelocytic, Acute Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome Secondary Aml Acute Myelocytic Leukemia Acute Myeloid Leukemia, Somatic Leukemia, Acute Myeloid, Somatic Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic Acute Myeloblastic Leukaemia Acute Myelogenous Leukaemia Aml - Acute Myeloid Leukemia Acute Myeloid Leukemia With Cebpa Somatic Mutations Aml With Cebpa Somatic Mutations Inherited Acute Myeloid Leukemia Familial Aml Inherited Aml Pure Familial Aml Pure Familial Acute Myeloid Leukemia Secondary Acute Myeloid Leukemia Therapy-Related Aml And Myelodysplastic Syndrome Acute Myeloid Leukemia, Secondary Acute Non-Lymphoblastic Leukemia Acute Non-Lymphocytic Leukemia Acute Biphenotypic Leukemia Acute Undifferentiated Leukemia Acute Myeloblastic Leukaemia With Multilineage Dysplasia Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission Acute Myeloid Leukaemia With Myelodysplasia-Related Features

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02211	CD226 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS16914	Cd226 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23356	Cd226 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P992205	Anti-CD226 Antibody		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CD226	MGD	MGI:3039602
Bos taurus	CD226	VGNC	VGNC:27013
Macaca mulatta	CD226	VGNC	VGNC:101435
Rattus norvegicus	CD226	RGD	RGD:1311513
Canis familiaris	CD226	VGNC	VGNC:38940
Felis catus	CD226	VGNC	VGNC:60598
Others	CD226	NCBI