CD314/NKG2D Antibody (YA4678)

Cat. No.: HY-P84986: Data Sheet COA User Guide for Antibodies
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CD314/NKG2D Antibody (YA4678) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to CD314/NKG2D.

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사이즈	재고	수량
20 μL	해외재고보유	Estimated Time of Arrival: December 31
50 μL	해외재고보유	Estimated Time of Arrival: December 31
100 μL	해외재고보유	Estimated Time of Arrival: December 31
250 μL	견적 받기

or 대량구매 문의

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
제품 설명

제품 설명

CD314/NKG2D Antibody (YA4678) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to CD314/NKG2D.

Host

Mouse

Clonality

Monoclonal

Species Reactivity

Human

SwissProt ID

P26718

Gene ID

22914 [NCBI]

Immunogen

Purified recombinant Human CD314

Application &
Dilution Ratio

Application	Dilution Ratio
ELISA ELISA: Enzyme Linked Immunosorbent Assay	1:5000-100000

Purity	affinity purified.	Conjugation	Non-conjugated
Modification	Unmodified

Appearance

Liquid

Formulation

Supplied in Phosphate-buffered solution.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

선적

Shipping with blue ice.

Background

Function：Functions as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-expressing tumor cells. Signaling involves calcium influx, culminating in the expression of TNF-alpha. Participates in NK cell-mediated bone marrow graft rejection. May play a regulatory role in differentiation and survival of NK cells. Binds to ligands belonging to various subfamilies of MHC class I-related glycoproteins including MICA, MICB, RAET1E, RAET1G, RAET1L/ULBP6, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4

Subcellular Localization：Cell membrane; Single-pass type II membrane protein

Expression：
Tissue_specificity:It is expressed in natural killer (NK) cells, CD8 (+) αβ and γδ T cells. It is expressed on almost all CD56+CD3- NK cells in freshly isolated peripheral blood mononuclear cells (PBMCs) . It is also expressed in interferon-producing cytotoxic dendritic cells (IKDCs) .

Induction:Up-regulated by interleukin IL15 in primary NK cells

Isoforms & Post-Translational Modification：P26718 has 1 isomers: P26718-1: 25304 Da (predicted).

Subunit：Homodimer; disulfide-linked. Heterohexamer composed of two subunits of KLRK1 and four subunits of HCST/DAP10. Interacts (via transmembrane domain) with HCST/DAP10 (via transmembrane domain); the interaction is required for KLRK1 NK cell surface and induces NK cell-mediated cytotoxicity. Does not interact with TYROBP. Interacts with CEACAM1; recruits PTPN6 that dephosphorylates VAV1 (PubMed:23696226)

Synonyms

NKG2-D type II integral membrane protein; Killer cell lectin-like receptor subfamily K member 1; NK cell receptor D; NKG2-D-activating NK receptor; CD antigen CD314; CD314 nanobody; NKG2D nanobody;

각종 서류

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COA (205 KB)

User Guide for Antibodies (1077 KB)