CD314/NKG2D Antibody (YA4678)
(Synonyms: NKG2-D type II integral membrane protein; Killer cell lectin-like receptor subfamily K member 1; NK cell receptor D; NKG2-D-activating NK receptor; CD antigen CD314; CD314 nanobody; NKG2D nanobody; )
Based on 1 Customer Validation
CD314/NKG2D Antibody (YA4678) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to CD314/NKG2D.
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Host:
Mouse
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Application:
ELISA
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Reactivity :
Human
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Formulation:
Supplied in Phosphate-buffered solution.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|
| Dilution Ratio | 1:5000-100000 |
Product Details
CD314/NKG2D Antibody (YA4678) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to CD314/NKG2D.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
Purified recombinant Human CD314
affinity purified.
Non-conjugated
Unmodified
Product Properties
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Appearance
Liquid
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Formulation
Supplied in Phosphate-buffered solution.
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Concentration
Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
CD314/NKG2D functions as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-expressing tumor cells. Signaling involves calcium influx, culminating in the expression of TNF-alpha. Participates in NK cell-mediated bone marrow graft rejection. May play a regulatory role in differentiation and survival of NK cells. Binds to ligands belonging to various subfamilies of MHC class I-related glycoproteins including MICA, MICB, RAET1E, RAET1G, RAET1L/ULBP6, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4
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Subcellular Localization
Cell membrane; Single-pass type II membrane protein
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Expression
Tissue_specificity:It is expressed in natural killer (NK) cells, CD8 (+) αβ and γδ T cells. It is expressed on almost all CD56+CD3- NK cells in freshly isolated peripheral blood mononuclear cells (PBMCs) . It is also expressed in interferon-producing cytotoxic dendritic cells (IKDCs) .
Induction:Up-regulated by interleukin IL15 in primary NK cells -
Isoforms & Post-Translational Modification
P26718 has 1 isomers: P26718-1: 25304 Da (predicted).
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Subunit
Homodimer; disulfide-linked. Heterohexamer composed of two subunits of KLRK1 and four subunits of HCST/DAP10. Interacts (via transmembrane domain) with HCST/DAP10 (via transmembrane domain); the interaction is required for KLRK1 NK cell surface and induces NK cell-mediated cytotoxicity. Does not interact with TYROBP. Interacts with CEACAM1; recruits PTPN6 that dephosphorylates VAV1 (PubMed:23696226)
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SwissProt ID
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Synonyms
NKG2-D type II integral membrane protein; Killer cell lectin-like receptor subfamily K member 1; NK cell receptor D; NKG2-D-activating NK receptor; CD antigen CD314; CD314 nanobody; NKG2D nanobody;
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