CLEC12A Antibody (YA4684)
(Synonyms: CLL1; MICL; CLL-1; DCAL-2; C-type lectin domain family 12 member A; CD371; CD371 nanobody; )CLEC12A Antibody (YA4684) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to CLEC12A.
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Host:
Mouse
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Application:
ELISA
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Reactivity :
Human
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Formulation:
Supplied in Phosphate-buffered solution.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|
| Dilution Ratio | 1:5000-100000 |
Product Details
CLEC12A Antibody (YA4684) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to CLEC12A.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
Purified recombinant Human CD371
affinity purified.
Non-conjugated
Unmodified
Product Properties
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Appearance
Liquid
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Formulation
Supplied in Phosphate-buffered solution.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
CLEC12A is a Myeloid inhibitory C-type lectin receptor that acts as a negative regulator of myeloid cell activation. Myeloid cell inhibition is required to limit proinflammatory pathways and protect against excessive inflammation. Specifically recognizes and binds various structures, such as neutrophil extracellular traps (NETs) or monosodium urate crystals. Also acts as a pattern-recognition receptor for pathogen-associated molecules, such as plasmodium hemozoin or mycobacterial micolic acid. Ligand-binding induces phosphorylation of its ITIM motif, followed by recruitment of tyrosine-protein phosphatases PTPN6 and PTPN11, which counteract tyrosine-protein kinase SYK, thereby preventing myeloid cell activation. Acts as a pattern-recognition receptor for NETs in neutrophils: specifically recognizes DNA in NETs, leading to inhibit neutrophil activation and limit further NET formation. This regulation is essential for controlling key neutrophil responses and limit NET-mediated inflammatory conditions. Also recognizes dead cells by acting as a receptor for monosodium urate crystals, leading to down-regulate neutrophil activation. Binding to monosodium urate crystals also promotes the type I interferon response. Acts as an inhibitor of natural killer (NK) cell cytotoxicity. Also acts as an ihibitor of dendritic cell maturation in an IL10-dependent manner[1][2][3][4][5][6][7][8][9].
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Subcellular Localization
Cell membrane; Single-pass type II membrane protein
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Expression
Tissue_specificity:It is primarily expressed in lymphoid tissues and immune cells, including natural killer (NK) cells, T cells, dendritic cells, and monocytes or macrophages (PubMed:14739280, PubMed:15238421, PubMed:15548716, PubMed:16239426, PubMed:16838277) . It can be detected (at the protein level) in macrophage-rich red pulp and lymph nodes in the spleen (PubMed:16838277) . It can also be detected in peripheral blood leukocytes, dendritic cells, bone marrow, monocytes, mononuclear leukocytes, and macrophages (PubMed:16838277) .
Induction:Down-regulated in activated leukocytes recruited to a site of inflammation -
Isoforms & Post-Translational Modification
Q5QGZ9 has 5 isomers: Q5QGZ9-2: 30762 Da (predicted); Q5QGZ9-1: 32040 Da (predicted); Q5QGZ9-3: 8965 Da (predicted); Q5QGZ9-4: 27276 Da (predicted); Q5QGZ9-5: 24449 Da (predicted).
Phosphorylated at Tyr-7 by SRC in the ITIM motif following ligand-binding, promoting recruitment of tyrosine-protein phosphatases PTPN6 and PTPN11;Highly N-glycosylated; glycosylation varies between cell types -
Subunit
Homodimer; disulfide-linked (By similarity). Interacts (when the ITIM motif is phosphorylated) with PTPN6 and PTPN11 (PubMed:14739280)
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SwissProt ID
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Synonyms
CLL1; MICL; CLL-1; DCAL-2; C-type lectin domain family 12 member A; CD371; CD371 nanobody;
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