CHAC1 Antibody (YA7973)(PBS only)

Cat. No.: HY-P88289A: Data Sheet User Guide for Antibodies
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CHAC1 Antibody (YA7973) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CHAC1.

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

CHAC1 Antibody (YA7973) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CHAC1.

Host

Mouse

Molecular Weight

Predicted band size: 24.2 kDa

Species Reactivity

Human, Mouse, Rat

SwissProt ID

Q9BUX1

Immunogen

Full length human recombinant protein of human CHAC1 produced in HEK293T cell.

Application &
Dilution Ratio

Application	Dilution Ratio
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:150-500
ICC/IF ICC/IF: Immunocytochemistry/Immunofluorescence	1:100-250

Purity	Affinity purified	Conjugation	Non-conjugated
Isotype	IgG1

Appearance

Liquid

Formulation

Supplied in PBS, pH 7.4.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides (PubMed:27913623). Glutathione depletion is an important factor for apoptosis initiation and execution. Acts as a pro-apoptotic component of the unfolded protein response pathway by mediating the pro-apoptotic effects of the ATF4-ATF3-DDIT3/CHOP cascade (PubMed:19109178). Negative regulator of Notch signaling pathway involved in embryonic neurogenesis: acts by inhibiting Notch cleavage by furin, maintaining Notch in an immature inactive form, thereby promoting neurogenesis in embryos (PubMed:22445366)

Subcellular Localization：Cytoplasm, cytosol,Golgi apparatus, trans-Golgi network

Expression：Induction: Induced by chemical activators of the unfolded protein response (UPR) such as tunicamycin, DTT and thapsigargin

Isoforms & Post-Translational Modification：Q9BUX1 has two isomers: Q9BUX1-1: 24418 Da (predicted); Q9BUX1-2: 19466 Da (predicted).

Subunit：Interacts with NOTCH1 (via extracellular region)

Synonyms

MGC4504

Documentation

User Guide for Antibodies (1077 KB)