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CHAC1 Antibody (YA7973)(PBS only)

(Synonyms: MGC4504)

CHAC1 Antibody (YA7973) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CHAC1.

For research use only. We do not sell to patients.
  • Host:

    Mouse

  • Isotype:

    IgG1

  • Application:

    IHC-P, ICC/IF

  • Reactivity :

    Human, Mouse, Rat

  • Formulation:

    Supplied in PBS, pH 7.4.

  • Conjugation:
    Non-conjugated
  • CHAC1 Antibody (YA7973)(PBS only) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Use of MCE Products

Applications

Application
IHC-P Info
IHC-P: Immunohistochemistry-Paraffin
ICC/IF Info
ICC/IF: Immunocytochemistry/
Immunofluorescence
Dilution Ratio 1:150-500 1:100-250

Product Details

Description

CHAC1 Antibody (YA7973) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CHAC1.

  • Host Mouse
  • Species Reactivity
    Human, Mouse, Rat
  • Calculated Molecular Weight Predicted band size: 24.2 kDa
Immunogen

Full length human recombinant protein of human CHAC1 produced in HEK293T cell.

Purification

Affinity purified

Conjugation

Non-conjugated

Isotype

IgG1

Product Properties

  • Appearance

    Liquid

  • Formulation

    Supplied in PBS, pH 7.4.

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    CHAC1 catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides. Glutathione depletion is an important factor for apoptosis initiation and execution. Acts as a pro-apoptotic component of the unfolded protein response pathway by mediating the pro-apoptotic effects of the ATF4-ATF3-DDIT3/CHOP cascade. Negative regulator of Notch signaling pathway involved in embryonic neurogenesis: acts by inhibiting Notch cleavage by furin, maintaining Notch in an immature inactive form, thereby promoting neurogenesis in embryos[1][2][3].

  • Subcellular Localization

    Cytoplasm, cytosol,Golgi apparatus, trans-Golgi network

  • Expression

    Induction: Induced by chemical activators of the unfolded protein response (UPR) such as tunicamycin, DTT and thapsigargin

  • Isoforms & Post-Translational Modification

    Q9BUX1 has two isomers: Q9BUX1-1: 24418 Da (predicted); Q9BUX1-2: 19466 Da (predicted).

  • Subunit

    Interacts with NOTCH1 (via extracellular region)

  • SwissProt ID

    Q9BUX1

  • Synonyms

    MGC4504

CHAC1 Antibody (YA7973)(PBS only) Related Classifications

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Minimum order quantity
100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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  • CHAC1 Antibody (YA7973)(PBS only) Product Image