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CHRNA2 Antibody (YA4300)(PBS only)

(Synonyms: Neuronal acetylcholine receptor subunit alpha-2, CHRNA2)

CHRNA2 Antibody (YA4300) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CHRNA2.

For research use only. We do not sell to patients.
  • Host:

    Mouse

  • Isotype:

    IgG1

  • Application:

    WB, ELISA

  • Reactivity :

    Human, Rat

  • Formulation:

    Supplied in PBS, pH 7.4.

  • Conjugation:
    Non-conjugated
  • CHRNA2 Antibody (YA4300)(PBS only) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Applications

Application
WB Info
WB: Western Blot
ELISA Info
ELISA: Enzyme Linked Immunosorbent Assay
Dilution Ratio 1:500-1:2000 1:10000

Product Details

Description

CHRNA2 Antibody (YA4300) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CHRNA2.

  • Host Mouse
  • Species Reactivity
    Human, Rat
  • Observed Molecular Weight
    Observed band size: 60 kDa Info
    Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
  • Calculated Molecular Weight Predicted band size: 60 kDa
Immunogen

Purified recombinant fragment of human CHRNA2 (AA: extra 27-264) expressed in E. Coli.

Purification

affinity purified.

Conjugation

Non-conjugated

Isotype

IgG1

Product Properties

  • Appearance

    Solution

  • Formulation

    Supplied in PBS, pH 7.4.

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    CHRNA2 component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter receptors formed by a collection of nAChR subunits known to mediate synaptic transmission in the nervous system and the neuromuscular junction. Each nAchR subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, cation permeability, and binding to allosteric modulators. CHRNA2 forms heteropentameric neuronal acetylcholine receptors with CHRNB2 and CHRNB4 and plays a role in nicotine dependence[1][2][3].

  • Subcellular Localization

    Synaptic cell membrane; Multi-pass membrane protein; Cell membrane; Multi-pass membrane protein

  • Subunit

    Neuronal AChR is composed of two different types of subunits: alpha and non-alpha (beta). CHRNA2/alpha-2 subunit can be combined to CHRNB2/beta-2 or CHRNB4/beta-4 to give rise to functional receptors. Both CHRNA2:CHRNB2 and CHRNA2:CHRNB4 nAChR complexes are heteropentamers with two subtypes: LS (low agonist sensitivity) with a (CHRNA2)3:(CHRNB2/4)2 and HS (high agonist sensitivity) with a (CHRNA2)2:(CHRNB2/4)3 stoichiometries; the subtypes differ in their subunit binding interfaces which are involved in ligand binding

  • SwissProt ID

    Q15822

  • Gene ID
    1135 [NCBI]
  • Synonyms

    Neuronal acetylcholine receptor subunit alpha-2, CHRNA2

CHRNA2 Antibody (YA4300)(PBS only) Related Classifications

MOQ
Minimum order quantity
100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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  • CHRNA2 Antibody (YA4300)(PBS only) Product Image