DDOST Antibody (YA8699)
(Synonyms: AGER1; CDG1R; OKSWcl45; OST; OST48; WBP1)DDOST Antibody (YA8699) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to DDOST.
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Host:
Mouse
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Isotype:
IgG2a
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Application:
WB, IHC-P
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Reactivity :
Human, Mouse, Rat
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
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Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|---|
| Dilution Ratio | 1:500-2000 | 1:150-500 |
Product Details
DDOST Antibody (YA8699) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to DDOST.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Calculated Molecular Weight Predicted band size: 46.1 kDa
Human recombinant protein fragment corresponding to amino acids 131-378 of human DDOST produced in E.coli.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG2a
Product Properties
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Appearance
Liquid
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
DDOST is a Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. Required for the assembly of both SST3A- and SS3B-containing OST complexes[1][2].
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Subcellular Localization
Endoplasmic reticulum membrane
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Isoforms & Post-Translational Modification
P39656 has three isomers: P39656-1: 50801 Da (predicted); P39656-2: 46577 Da (predicted); P39656-3: 49020 Da (predicted).
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Subunit
Component of the oligosaccharyltransferase (OST) complex (PubMed:31831667, PubMed:36697828, PubMed:38670073)
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SwissProt ID
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Synonyms
AGER1; CDG1R; OKSWcl45; OST; OST48; WBP1
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