DDX56 Antibody (YA8051)(PBS only)

Cat. No.: HY-P88367A: Data Sheet User Guide for Antibodies
FAQs
Technical Support

DDX56 Antibody (YA8051) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to DDX56.

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

* Please select Quantity before adding items.

WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

DDX56 Antibody (YA8051) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to DDX56.

Host

Mouse

Species Reactivity

Human, Mouse, Rat

SwissProt ID

Q9NY93

Immunogen

Human recombinant protein fragment corresponding to amino acids 323-547 of human DDX56 produced in E.coli.

Application &
Dilution Ratio

Application	Dilution Ratio
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:100-200
ICC/IF ICC/IF: Immunocytochemistry/Immunofluorescence	1:100-250

Purity	Affinity purified	Conjugation	Non-conjugated
Isotype	IgG1

Appearance

Liquid

Formulation

Supplied in PBS, pH 7.4.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Nucleolar RNA helicase that plays a role in various biological processes including innate immunity, ribosome biogenesis or nucleolus organization (PubMed:31340999, PubMed:33789112). Plays an essential role in maintaining nucleolar integrity in planarian stem cells (PubMed:33789112). Maintains embryonic stem cells proliferation by conventional regulation of ribosome assembly and interaction with OCT4 and POU5F1 complex (By similarity). Regulates antiviral innate immunity by inhibiting the virus-triggered signaling nuclear translocation of IRF3 (PubMed:31340999). Mechanistically, acts by disrupting the interaction between IRF3 and importin IPO5 (PubMed:31340999). May play a role in later stages of the processing of the pre-ribosomal particles leading to mature 60S ribosomal subunits. Has intrinsic ATPase activity|(Microbial infection) Helicase activity is important for packaging viral RNA into virions during West Nile virus infection|(Microbial infection) Plays a positive role in foot-and-mouth disease virus replication by inhibiting the phosphorylation of IRF3 leading to inhibition of type I interferon|(Microbial infection) Plays a positive role in EMCV replication by interrupting IRF3 phosphorylation and its nucleus translocation

Subcellular Localization：Nucleus, nucleolus

Expression：
Tissue_Specificity: Detected in heart, brain, liver, pancreas, placenta and lung

Isoforms & Post-Translational Modification：Q9NY93 has two isomers: Q9NY93-1: 61590 Da (predicted); Q9NY93-2: 57275 Da (predicted).

Subunit：May form homooligomeric complexes

Synonyms

DDX21; DDX26; NOH61

Documentation

User Guide for Antibodies (1077 KB)