DDX56 Antibody (YA8051)(PBS only)
(Synonyms: DDX21; DDX26; NOH61)DDX56 Antibody (YA8051) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to DDX56.
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Host:
Mouse
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Isotype:
IgG1
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Application:
IHC-P, ICC/IF
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in PBS, pH 7.4.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|---|
| Dilution Ratio | 1:100-200 | 1:100-250 |
Product Details
DDX56 Antibody (YA8051) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to DDX56.
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Host Mouse
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Species ReactivityHuman, Mouse, Rat
Human recombinant protein fragment corresponding to amino acids 323-547 of human DDX56 produced in E.coli.
Affinity purified
Non-conjugated
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS, pH 7.4.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
DDX56 is a Nucleolar RNA helicase that plays a role in various biological processes including innate immunity, ribosome biogenesis or nucleolus organization. Plays an essential role in maintaining nucleolar integrity in planarian stem cells. Maintains embryonic stem cells proliferation by conventional regulation of ribosome assembly and interaction with OCT4 and POU5F1 complex. Regulates antiviral innate immunity by inhibiting the virus-triggered signaling nuclear translocation of IRF3. Mechanistically, acts by disrupting the interaction between IRF3 and importin IPO5. May play a role in later stages of the processing of the pre-ribosomal particles leading to mature 60S ribosomal subunits. Has intrinsic ATPase activity|(Microbial infection) Helicase activity is important for packaging viral RNA into virions during West Nile virus infection|(Microbial infection) Plays a positive role in foot-and-mouth disease virus replication by inhibiting the phosphorylation of IRF3 leading to inhibition of type I interferon|(Microbial infection) Plays a positive role in EMCV replication by interrupting IRF3 phosphorylation and its nucleus translocation[1][2].
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Subcellular Localization
Nucleus, nucleolus
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Expression
Tissue_Specificity: Detected in heart, brain, liver, pancreas, placenta and lung -
Isoforms & Post-Translational Modification
Q9NY93 has two isomers: Q9NY93-1: 61590 Da (predicted); Q9NY93-2: 57275 Da (predicted).
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Subunit
May form homooligomeric complexes
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SwissProt ID
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Synonyms
DDX21; DDX26; NOH61
Documentation
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