2. Antibodies
  3. Primary Antibodies
  4. Monoclonal Antibodies Recombinant Antibodies
  5. Desmocollin 3 Antibody (YA1702)

Desmocollin 3 Antibody (YA1702)

Cat. No.: HY-P81957
User Guide for Antibodies Technical Support

Desmocollin 3 Antibody (YA1702) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Desmocollin 3.

For research use only. We do not sell to patients.

Size Price Stock Quantity
20 μL Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks
50 μL Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks
100 μL Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks
250 μL   Get quote  
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Top Publications Citing Use of Products
  • WB: Western Blot;
  • IHC-P: Immunohistochemistry-Paraffin;
  • IHC-F: Immunohistochemistry-Frozen;
  • ICC/IF: Immunocytochemistry/Immunofluorescence;
  • IF-Tissue: Immunofluorescence-Tissue;
  • mIHC: Multiplex Immunohistochemical;
  • IP: Immunoprecipitation;
  • ChIP: Chromatin Immunoprecipitation;
  • FC: Flow Cytometry;
  • ELISA: Enzyme Linked Immunosorbent Assay

  • Product Detail

  • Background

  • Documentation

Description

Desmocollin 3 Antibody (YA1702) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Desmocollin 3.
Host

Rabbit
Clonality

Recombinant, Monoclonal
Molecular Weight
Predicted band size: 100 kDa;
Observed band size: 100 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Species Reactivity
Human
SwissProt ID
Gene ID
Immunogen

A synthetic peptide of human Desmocollin 3
Application &
Dilution Ratio
Application Dilution Ratio
WB
WB: Western Blot
1:500-1:1000
ICC/IF
ICC/IF: Immunocytochemistry/Immunofluorescence
1:50-1:200
Sensitivity Endogenous Purity Affinity Purified
Conjugation Non-conjugated Modification Unmodified
Isotype IgG  
Appearance

Liquid
Formulation

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.
Background
Function：A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (By similarity). Required for cell-cell adhesion in the epidermis, as a result required for the maintenance of the dermal cohesion and the dermal barrier function (PubMed:19717567). Required for cell-cell adhesion of epithelial cell layers surrounding the telogen hair club, as a result plays an important role in telogen hair shaft anchorage (By similarity). Essential for successful completion of embryo compaction and embryo development (By similarity)
Subcellular Localization：Cell membrane; Single-pass type I membrane protein; Cell junction, desmosome; Cytoplasm
Expression：
Tissue_specificity:Expressed throughout the basal and spinous layer of the epidermis with weak expression in the granular layer (at protein level) (PubMed:19717567, PubMed:7665906) . Also expressed in the buccal mucosa, esophagus and cervix (at protein level) (PubMed:7665906)

Induction:Induced in the hours following cyclic mechanical strain in keratinocytes
Isoforms & Post-Translational Modification：Q14574 has 2 isomers: Q14574-1: 99969 Da (predicted); Q14574-2: 93454 Da (predicted).
Subunit：May form homodimers (PubMed:19717567). Interacts with DSG1; there is evidence to suggest that the interaction promotes cell-cell adhesion of keratinocytes (PubMed:19717567)
Database

Entrez Gene: 1825 Human

SwissProt: Q14574 Human

OMIM: 613102 Human

Research Field

Signal Transduction
Synonyms
Cadherin family member 3; Desmocollin-4; HT-CP
Documentation
User Guide for Antibodies (1077 KB)

Desmocollin 3 Antibody (YA1702) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Desmocollin 3 Antibody (YA1702)
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