Desmocollin 3 Antibody (YA1702)
(Synonyms: Cadherin family member 3; Desmocollin-4; HT-CP)Desmocollin 3 Antibody (YA1702) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Desmocollin 3.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, ICC/IF
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Reactivity :
Human
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Formulation:
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
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Conjugation:
Non-conjugated
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|---|
| Dilution Ratio | 1:500-1:1000 | 1:50-1:200 |
Product Details
Desmocollin 3 Antibody (YA1702) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Desmocollin 3.
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Host Rabbit
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Clonality Recombinant, Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 100 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 100 kDa
A synthetic peptide of human Desmocollin 3
Endogenous
Affinity Purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Desmocollin 3 is an A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion. Required for cell-cell adhesion in the epidermis, as a result required for the maintenance of the dermal cohesion and the dermal barrier function. Required for cell-cell adhesion of epithelial cell layers surrounding the telogen hair club, as a result plays an important role in telogen hair shaft anchorage. Essential for successful completion of embryo compaction and embryo development[1].
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Subcellular Localization
Cell membrane; Single-pass type I membrane protein; Cell junction, desmosome; Cytoplasm
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Expression
Tissue_specificity:Expressed throughout the basal and spinous layer of the epidermis with weak expression in the granular layer (at protein level) (PubMed:19717567, PubMed:7665906) . Also expressed in the buccal mucosa, esophagus and cervix (at protein level) (PubMed:7665906)
Induction:Induced in the hours following cyclic mechanical strain in keratinocytes -
Isoforms & Post-Translational Modification
Q14574 has 2 isomers: Q14574-1: 99969 Da (predicted); Q14574-2: 93454 Da (predicted).
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Subunit
May form homodimers (PubMed:19717567). Interacts with DSG1; there is evidence to suggest that the interaction promotes cell-cell adhesion of keratinocytes (PubMed:19717567)
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SwissProt ID
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Synonyms
Cadherin family member 3; Desmocollin-4; HT-CP
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Research Field
Signal Transduction
Documentation
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